Angiomatoid fibrous histiocytoma: novel MR imaging findings.

Journal Article (Journal Article)

OBJECTIVE: To describe novel MR imaging features, and clinical characteristics of soft tissue angiomatoid fibrous histiocytoma (AFH) at presentation, local recurrence, and metastases. MATERIALS AND METHODS: We described the MRI findings of six cases of histologically proven AFH. Pathologic findings, clinical presentation, and outcome were reviewed. RESULTS: Lesions were primarily cystic. At initial presentation, tumors were surrounded by low signal intensity fibrous pseudocapsule. High signal intensity consistent with the lymphoplasmacytic infiltrate was seen in T2-weighted and post-contrast images as a rim over the hypointense pseudocapsule (double rim sign). High signal intensity infiltrating tumoral cords extended into adjacent tissues, through pseudocapsular defects on T2-weighted and post-contrast images. The cystic component and tumor cell nodularity were demonstrated at post-contrast images. Clinically, lesions were often thought to be benign, underwent marginal resection, developed local recurrence, and one developed second recurrence consisting of metastases. Recurrent tumors appeared as multiple masses, misinterpreted as post-surgical changes. An intramuscular recurrence demonstrated double rim and infiltrating margin. CONCLUSIONS: A predominantly well-circumscribed, primarily cystic mass with double-rim and marginal infiltration on MRI suggests the possibility of AFH, in particular in child or young adult. Inclusion of these novel observations in AFH differential diagnosis may have a significant impact on treatment and prevention of recurrence.

Full Text

Duke Authors

Cited Authors

  • Martinez, SJ; Moreno, CC; Vinson, EN; Dodd, LG; Brigman, BE

Published Date

  • May 2016

Published In

Volume / Issue

  • 45 / 5

Start / End Page

  • 661 - 670

PubMed ID

  • 26919861

Electronic International Standard Serial Number (EISSN)

  • 1432-2161

Digital Object Identifier (DOI)

  • 10.1007/s00256-016-2344-4


  • eng

Conference Location

  • Germany