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Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.

Publication ,  Journal Article
Qiu, L-X; Hua, R-X; Cheng, L; He, J; Wang, M-Y; Zhou, F; Zhu, X-D; Sun, M-H; Zhou, X-Y; Li, J; Wang, Y-N; Yang, Y-J; Wang, J-C; Jin, L ...
Published in: Oncotarget
March 29, 2016

Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chinese population. Our results showed that the G allele was strongly associated with a decreased GCa risk in the study population [GG vs. AA, odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.31-0.73; AG/GG vs. AA, OR = 0.82, 95% CI = 0.68-0.99; GG vs. AA/AG, OR = 0.48, 95% CI = 0.32-0.74]. These associations remained significant in subgroups of age, tumor site, drinking and smoking status. Moreover, this association was supported by an additional meta-analysis of published studies. In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations.

Duke Scholars

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

March 29, 2016

Volume

7

Issue

13

Start / End Page

15930 / 15936

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Mucin-1
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Qiu, L.-X., Hua, R.-X., Cheng, L., He, J., Wang, M.-Y., Zhou, F., … Wei, Q.-Y. (2016). Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population. Oncotarget, 7(13), 15930–15936. https://doi.org/10.18632/oncotarget.7527
Qiu, Li-Xin, Rui-Xi Hua, Lei Cheng, Jing He, Meng-Yun Wang, Fei Zhou, Xiao-Dong Zhu, et al. “Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.Oncotarget 7, no. 13 (March 29, 2016): 15930–36. https://doi.org/10.18632/oncotarget.7527.
Qiu L-X, Hua R-X, Cheng L, He J, Wang M-Y, Zhou F, et al. Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population. Oncotarget. 2016 Mar 29;7(13):15930–6.
Qiu, Li-Xin, et al. “Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.Oncotarget, vol. 7, no. 13, Mar. 2016, pp. 15930–36. Pubmed, doi:10.18632/oncotarget.7527.
Qiu L-X, Hua R-X, Cheng L, He J, Wang M-Y, Zhou F, Zhu X-D, Sun M-H, Zhou X-Y, Li J, Wang Y-N, Yang Y-J, Wang J-C, Jin L, Guo W-J, Wei Q-Y. Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population. Oncotarget. 2016 Mar 29;7(13):15930–15936.

Published In

Oncotarget

DOI

EISSN

1949-2553

Publication Date

March 29, 2016

Volume

7

Issue

13

Start / End Page

15930 / 15936

Location

United States

Related Subject Headings

  • Stomach Neoplasms
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Mucin-1
  • Middle Aged
  • Male
  • Humans
  • Genotype
  • Genetic Predisposition to Disease