Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population.

Published

Journal Article

Published data on the association between the MUC1 rs4072037A > G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chinese population. Our results showed that the G allele was strongly associated with a decreased GCa risk in the study population [GG vs. AA, odds ratio (OR) = 0.47, 95% confidence interval (CI) = 0.31-0.73; AG/GG vs. AA, OR = 0.82, 95% CI = 0.68-0.99; GG vs. AA/AG, OR = 0.48, 95% CI = 0.32-0.74]. These associations remained significant in subgroups of age, tumor site, drinking and smoking status. Moreover, this association was supported by an additional meta-analysis of published studies. In summary, these results suggest that the MUC1 rs4072037G allele may be a low-penetrating protection factor for GCa risk in Chinese populations.

Full Text

Duke Authors

Cited Authors

  • Qiu, L-X; Hua, R-X; Cheng, L; He, J; Wang, M-Y; Zhou, F; Zhu, X-D; Sun, M-H; Zhou, X-Y; Li, J; Wang, Y-N; Yang, Y-J; Wang, J-C; Jin, L; Guo, W-J; Wei, Q-Y

Published Date

  • March 29, 2016

Published In

Volume / Issue

  • 7 / 13

Start / End Page

  • 15930 - 15936

PubMed ID

  • 26910281

Pubmed Central ID

  • 26910281

Electronic International Standard Serial Number (EISSN)

  • 1949-2553

Digital Object Identifier (DOI)

  • 10.18632/oncotarget.7527

Language

  • eng

Conference Location

  • United States