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Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls.

Publication ,  Journal Article
Kang, X; Liu, H; Onaitis, MW; Liu, Z; Owzar, K; Han, Y; Su, L; Wei, Y; Hung, RJ; Brhane, Y; McLaughlin, J; Brennan, P; Bickeböller, H; Wu, X ...
Published in: Carcinogenesis
March 2016

Centrosome abnormalities are often observed in premalignant lesions and in situ tumors and have been associated with aneuploidy and tumor development. We investigated the associations of 9354 single-nucleotide polymorphisms (SNPs) in 106 centrosomal genes with lung cancer risk by first using the summary data from six published genome-wide association studies (GWASs) of the Transdisciplinary Research in Cancer of the Lung (TRICL) (12,160 cases and 16 838 controls) and then conducted in silico replication in two additional independent lung cancer GWASs of Harvard University (984 cases and 970 controls) and deCODE (1319 cases and 26,380 controls). A total of 44 significant SNPs with false discovery rate (FDR) ≤ 0.05 were mapped to one novel gene FGFR1OP and two previously reported genes (TUBB and BRCA2). After combined the results from TRICL with those from Harvard and deCODE, the most significant association (P combined = 8.032 × 10(-6)) was with rs151606 within FGFR1OP. The rs151606 T>G was associated with an increased risk of lung cancer [odds ratio (OR) = 1.10, 95% confidence interval (95% CI) = 1.05-1.14]. Another significant tagSNP rs12212247 T>C (P combined = 9.589 × 10(-6)) was associated with a decreased risk of lung cancer (OR = 0.93, 95% CI = 0.90-0.96). Further in silico functional analyzes revealed that rs151606 might affect transcriptional regulation and result in decreased FGFR1OP expression (P trend = 0.022). The findings shed some new light on the role of centrosome abnormalities in the susceptibility to lung carcinogenesis.

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Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

March 2016

Volume

37

Issue

3

Start / End Page

280 / 289

Location

England

Related Subject Headings

  • Risk Factors
  • Proto-Oncogene Proteins
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
 

Citation

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Kang, X., Liu, H., Onaitis, M. W., Liu, Z., Owzar, K., Han, Y., … Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team, . (2016). Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls. Carcinogenesis, 37(3), 280–289. https://doi.org/10.1093/carcin/bgw014
Kang, Xiaozheng, Hongliang Liu, Mark W. Onaitis, Zhensheng Liu, Kouros Owzar, Younghun Han, Li Su, et al. “Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls.Carcinogenesis 37, no. 3 (March 2016): 280–89. https://doi.org/10.1093/carcin/bgw014.
Kang X, Liu H, Onaitis MW, Liu Z, Owzar K, Han Y, et al. Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls. Carcinogenesis. 2016 Mar;37(3):280–9.
Kang, Xiaozheng, et al. “Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls.Carcinogenesis, vol. 37, no. 3, Mar. 2016, pp. 280–89. Pubmed, doi:10.1093/carcin/bgw014.
Kang X, Liu H, Onaitis MW, Liu Z, Owzar K, Han Y, Su L, Wei Y, Hung RJ, Brhane Y, McLaughlin J, Brennan P, Bickeböller H, Rosenberger A, Houlston RS, Caporaso N, Landi MT, Heinrich J, Risch A, Wu X, Ye Y, Christiani DC, Amos CI, Wei Q, Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team. Polymorphisms of the centrosomal gene (FGFR1OP) and lung cancer risk: a meta-analysis of 14,463 cases and 44,188 controls. Carcinogenesis. 2016 Mar;37(3):280–289.
Journal cover image

Published In

Carcinogenesis

DOI

EISSN

1460-2180

Publication Date

March 2016

Volume

37

Issue

3

Start / End Page

280 / 289

Location

England

Related Subject Headings

  • Risk Factors
  • Proto-Oncogene Proteins
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease