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Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study.

Publication ,  Journal Article
Scioli-Salter, E; Forman, DE; Otis, JD; Tun, C; Allsup, K; Marx, CE; Hauger, RL; Shipherd, JC; Higgins, D; Tyzik, A; Rasmusson, AM
Published in: J Rehabil Res Dev
2016

This pilot study assessed the effects of cardiopulmonary exercise testing and cardiorespiratory fitness on plasma neuropeptide Y (NPY), allopregnanolone and pregnanolone (ALLO), cortisol, and dehydroepiandrosterone (DHEA), and their association with pain sensitivity. Medication-free trauma-exposed participants were either healthy (n = 7) or experiencing comorbid chronic pain/posttraumatic stress disorder (PTSD) (n = 5). Peak oxygen consumption (VO2) during exercise testing was used to characterize cardiorespiratory fitness. Peak VO2 correlated with baseline and peak NPY levels (r = 0.66, p < 0.05 and r = 0.69, p < 0.05, respectively), as well as exercise-induced changes in ALLO (r = 0.89, p < 0.001) and peak ALLO levels (r = 0.71, p < 0.01). NPY levels at the peak of exercise correlated with pain threshold 30 min after exercise (r = 0.65, p < 0.05), while exercise-induced increases in ALLO correlated with pain tolerance 30 min after exercise (r = 0.64, p < 0.05). In contrast, exercise-induced changes in cortisol and DHEA levels were inversely correlated with pain tolerance after exercise (r = -0.69, p < 0.05 and r = -0.58, p < 0.05, respectively). These data suggest that cardiorespiratory fitness is associated with higher plasma NPY levels and increased ALLO responses to exercise, which in turn relate to pain sensitivity. Future work will examine whether progressive exercise training increases cardiorespiratory fitness in association with increases in NPY and ALLO and reductions in pain sensitivity in chronic pain patients with PTSD.

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Published In

J Rehabil Res Dev

DOI

EISSN

1938-1352

Publication Date

2016

Volume

53

Issue

1

Start / End Page

95 / 106

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Rehabilitation
  • Pilot Projects
  • Pain Threshold
  • Male
  • Humans
  • Female
  • Exercise Therapy
  • Exercise Test
  • Exercise
 

Citation

APA
Chicago
ICMJE
MLA
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Scioli-Salter, E., Forman, D. E., Otis, J. D., Tun, C., Allsup, K., Marx, C. E., … Rasmusson, A. M. (2016). Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study. J Rehabil Res Dev, 53(1), 95–106. https://doi.org/10.1682/JRRD.2014.10.0267
Scioli-Salter, Erica, Daniel E. Forman, John D. Otis, Carlos Tun, Kelly Allsup, Christine E. Marx, Richard L. Hauger, et al. “Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study.J Rehabil Res Dev 53, no. 1 (2016): 95–106. https://doi.org/10.1682/JRRD.2014.10.0267.
Scioli-Salter E, Forman DE, Otis JD, Tun C, Allsup K, Marx CE, et al. Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study. J Rehabil Res Dev. 2016;53(1):95–106.
Scioli-Salter, Erica, et al. “Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study.J Rehabil Res Dev, vol. 53, no. 1, 2016, pp. 95–106. Pubmed, doi:10.1682/JRRD.2014.10.0267.
Scioli-Salter E, Forman DE, Otis JD, Tun C, Allsup K, Marx CE, Hauger RL, Shipherd JC, Higgins D, Tyzik A, Rasmusson AM. Potential neurobiological benefits of exercise in chronic pain and posttraumatic stress disorder: Pilot study. J Rehabil Res Dev. 2016;53(1):95–106.

Published In

J Rehabil Res Dev

DOI

EISSN

1938-1352

Publication Date

2016

Volume

53

Issue

1

Start / End Page

95 / 106

Location

United States

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Rehabilitation
  • Pilot Projects
  • Pain Threshold
  • Male
  • Humans
  • Female
  • Exercise Therapy
  • Exercise Test
  • Exercise