Copper-catalyzed aminotrifluoromethylation of alkenes: A facile synthesis of CF3-containing lactams

Journal Article (Journal Article)

Copper-catalyzed aminotrifluoromethylation of alkenes using amides as nucleophiles has been developed. It provides a rapid and efficient access to a variety of CF3-containing lactams. The reaction proceeds under mild conditions with a good scope and functional group tolerance, offering a valuable method to prepare CF3-containing lactams that are of great potential in pharmaceuticals and agrochemicals.

Full Text

Duke Authors

Cited Authors

  • Shen, K; Wang, Q

Published Date

  • February 1, 2016

Published In

Volume / Issue

  • 3 / 2

Start / End Page

  • 222 - 226

Electronic International Standard Serial Number (EISSN)

  • 2052-4129

International Standard Serial Number (ISSN)

  • 2052-4110

Digital Object Identifier (DOI)

  • 10.1039/c5qo00353a

Citation Source

  • Scopus