Influence of ozone on pentobarbital pharmacokinetics in mice.


Journal Article

Previous studies have indicated that acute exposure to ambient concentrations of ozone (O3) as low as 196 micrograms/m3 (0.1 ppm) increases pentobarbital (PEN)-induced sleeping time in female mice. To elucidate potential mechanisms involved, additional studies were performed. A 3 h exposure to 9800 micrograms O3/m3 (5 ppm) did not affect brain concentrations of PEN at time of awakening, even though sleeping time was increased. Exposure for 3 h to 9800 micrograms O3/m3 (5 ppm) did not alter the pattern of brain or plasma metabolites of PEN. Pentobarbital clearance followed first-order kinetics with a one-compartment model. Mice exposed to 9800 micrograms O3/m3 (5 ppm) for 3 h had a 106% increase in the plasma half-life of pentobarbital; at 1960 micrograms O3/m3 (1 ppm) for 3 h, a 71% increase was observed. It therefore appears possible that PEN-induced sleeping time might be increased due to an decrease in hepatic metabolism of PEN.

Full Text

Cited Authors

  • Graham, JA; Menzel, DB; Mole, ML; Miller, FJ; Gardner, DE

Published Date

  • February 1985

Published In

Volume / Issue

  • 24 / 2-3

Start / End Page

  • 163 - 170

PubMed ID

  • 3983969

Pubmed Central ID

  • 3983969

Electronic International Standard Serial Number (EISSN)

  • 1879-3169

International Standard Serial Number (ISSN)

  • 0378-4274

Digital Object Identifier (DOI)

  • 10.1016/0378-4274(85)90053-0


  • eng