A short history of dapsone, or an alternative model of drug development.


Journal Article (Review)

From 1936 until 1996, the drug dapsone treated a diverse array of diseases, including tuberculosis, leprosy, malaria, and AIDS-related pneumonia. This article explores how dapsone transformed from a cure for one disease into a treatment for a totally different malady. This process of reinvention in the clinic represents an alternative model of drug development that the historical literature, focused on success in the laboratory, has largely ignored. The core of the paper discusses the reinvention of dapsone as an antimalarial in the Vietnam War through trials led by Robert J. T. Joy, a physician and military officer. As a case study, it offers a fresh perspective on the clinic-as-laboratory approach that other scholars have addressed in a civilian context. Viewing the randomized clinical trial (RCT) through a military prism will demonstrate how a combat environment combined with the regimentation of the armed forces affected the standard methodology of the RCT.

Full Text

Duke Authors

Cited Authors

  • Barr, J

Published Date

  • October 2011

Published In

Volume / Issue

  • 66 / 4

Start / End Page

  • 425 - 467

PubMed ID

  • 20966036

Pubmed Central ID

  • 20966036

Electronic International Standard Serial Number (EISSN)

  • 1468-4373

International Standard Serial Number (ISSN)

  • 0022-5045

Digital Object Identifier (DOI)

  • 10.1093/jhmas/jrq068


  • eng