Evolving the use of peptides as components of biomaterials.

Published

Journal Article

This manuscript is part of a debate on the statement that "the use of short synthetic adhesion peptides, like RGD, is the best approach in the design of biomaterials that guide cell behavior for regenerative medicine and tissue engineering". We take the position that although there are some acknowledged disadvantages of using short peptide ligands within biomaterials, it is not necessary to discard the notion of using peptides within biomaterials entirely, but rather to reinvent and evolve their use. Peptides possess advantageous chemical definition, access to non-native chemistries, amenability to de novo design, and applicability within parallel approaches. Biomaterials development programs that require such aspects may benefit from a peptide-based strategy.

Full Text

Duke Authors

Cited Authors

  • Collier, JH; Segura, T

Published Date

  • June 2011

Published In

Volume / Issue

  • 32 / 18

Start / End Page

  • 4198 - 4204

PubMed ID

  • 21515167

Pubmed Central ID

  • 21515167

Electronic International Standard Serial Number (EISSN)

  • 1878-5905

International Standard Serial Number (ISSN)

  • 0142-9612

Digital Object Identifier (DOI)

  • 10.1016/j.biomaterials.2011.02.030

Language

  • eng