Directed intermixing in multicomponent self-assembling biomaterials.
Journal Article (Journal Article)
The noncovalent coassembly of multiple different peptides can be a useful route for producing multifunctional biomaterials. However, to date, such materials have almost exclusively been investigated as homogeneous self-assemblies, having functional components uniformly distributed throughout their supramolecular structures. Here we illustrate control over the intermixing of multiple different self-assembling peptides, in turn providing a simple but powerful means for modulating these materials' mechanical and biological properties. In β-sheet fibrillizing hydrogels, significant increases in stiffening could be achieved using heterobifunctional cross-linkers by sequestering peptides bearing different reactive groups into distinct populations of fibrils, thus favoring interfibril cross-linking. Further, by specifying the intermixing of RGD-bearing peptides in 2-D and 3-D self-assemblies, the growth of HUVECs and NIH 3T3 cells could be significantly modulated. This approach may be immediately applicable toward a wide variety of self-assembling systems that form stable supramolecular structures.
Full Text
Duke Authors
Cited Authors
- Gasiorowski, JZ; Collier, JH
Published Date
- October 2011
Published In
Volume / Issue
- 12 / 10
Start / End Page
- 3549 - 3558
PubMed ID
- 21863894
Pubmed Central ID
- PMC3190078
Electronic International Standard Serial Number (EISSN)
- 1526-4602
International Standard Serial Number (ISSN)
- 1525-7797
Digital Object Identifier (DOI)
- 10.1021/bm200763y
Language
- eng