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Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin.

Publication ,  Journal Article
Jing, P; Rudra, JS; Herr, AB; Collier, JH
Published in: Biomacromolecules
September 2008

Biomaterials constructed from self-assembling peptides, peptide derivatives, and peptide-polymer conjugates are receiving increasing attention as defined matrices for tissue engineering, controlled therapeutic release, and in vitro cell expansion, but many are constructed from peptide structures not typically found in the human extracellular matrix. Here we report a self-assembling biomaterial constructed from a designed peptide inspired by the coiled coil domain of human fibrin, the major protein constituent of blood clots and the provisional scaffold of wound healing. Targeted substitutions were made in the residues forming the interface between coiled coil strands for a 37-amino acid peptide from human fibrinogen to stabilize the coiled coil peptide bundle, while the solvent-exposed residues were left unchanged to provide a surface similar to that of the native protein. This peptide, which self-assembled into coiled coil dimers and tetramers, was then used to produce triblock peptide-PEG-peptide bioconjugates that self-assembled into viscoelastic hydrogel biomaterials.

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Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

September 2008

Volume

9

Issue

9

Start / End Page

2438 / 2446

Related Subject Headings

  • Protein Structure, Secondary
  • Protein Folding
  • Protein Conformation
  • Polymers
  • Polyethylene Glycols
  • Peptides
  • Molecular Sequence Data
  • Models, Molecular
  • Hydrogels
  • Humans
 

Citation

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Jing, P., Rudra, J. S., Herr, A. B., & Collier, J. H. (2008). Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. Biomacromolecules, 9(9), 2438–2446. https://doi.org/10.1021/bm800459v
Jing, Peng, Jai S. Rudra, Andrew B. Herr, and Joel H. Collier. “Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin.Biomacromolecules 9, no. 9 (September 2008): 2438–46. https://doi.org/10.1021/bm800459v.
Jing P, Rudra JS, Herr AB, Collier JH. Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. Biomacromolecules. 2008 Sep;9(9):2438–46.
Jing, Peng, et al. “Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin.Biomacromolecules, vol. 9, no. 9, Sept. 2008, pp. 2438–46. Epmc, doi:10.1021/bm800459v.
Jing P, Rudra JS, Herr AB, Collier JH. Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin. Biomacromolecules. 2008 Sep;9(9):2438–2446.
Journal cover image

Published In

Biomacromolecules

DOI

EISSN

1526-4602

ISSN

1525-7797

Publication Date

September 2008

Volume

9

Issue

9

Start / End Page

2438 / 2446

Related Subject Headings

  • Protein Structure, Secondary
  • Protein Folding
  • Protein Conformation
  • Polymers
  • Polyethylene Glycols
  • Peptides
  • Molecular Sequence Data
  • Models, Molecular
  • Hydrogels
  • Humans