Isolated seizures in rats do not cause neuronal injury.


Journal Article

BACKGROUND: Previous studies have shown that status epilepticus can lead to neuronal injury. However, the effect of a small number of isolated seizures is uncertain. METHODS: We used structural MRI and neuropathology to study the effects of isolated seizures induced by kainic acid (KA), (RS)-2-amino-3-(3-hydroxy-5-tert-butylisoxazole-4-yl)propanoic acid (ATPA), and α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate in rats. A group of animals received normal saline. After seizure induction, animals were followed for 12 weeks. RESULTS: ATPA and KA led to small but significant increases in ADC. There were no changes in T2 signal intensity or hippocampal volume. Blinded pathological examination showed no differences between animals receiving saline or glutamatergic agents. CONCLUSION: Our study suggests that isolated seizures cause minimal neuronal injury in rats.

Full Text

Duke Authors

Cited Authors

  • Acosta, MT; Munashinge, J; Zhang, L; Guerron, DA; Vortmeyer, A; Theodore, WH

Published Date

  • January 2012

Published In

Volume / Issue

  • 125 / 1

Start / End Page

  • 30 - 37

PubMed ID

  • 21615350

Pubmed Central ID

  • 21615350

Electronic International Standard Serial Number (EISSN)

  • 1600-0404

Digital Object Identifier (DOI)

  • 10.1111/j.1600-0404.2011.01521.x


  • eng

Conference Location

  • Denmark