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Short-term traffic related exposures and biomarkers of nitro-PAH exposure and oxidative DNA damage.

Publication ,  Journal Article
Neophytou, AM; Hart, JE; Chang, Y; Zhang, JJ; Smith, TJ; Garshick, E; Laden, F
Published in: Toxics
September 2014

Exposure to vehicle exhaust has been associated with cardiac and respiratory disease, lung cancer, and greater overall mortality. We investigated whether amino- polycyclic aromatic hydrocarbon (amino-PAH) metabolites of nitro-PAHs could be used as biomarkers of these exposures. Pre- and post-shift urine samples were collected at the beginning and end of a work week from 82 male U.S trucking industry workers. We used repeated-measures analysis to examine associations of total 1- and 2-aminonaphthalene (1 & 2-AN) and 1-aminopyrene (1-AP) urinary concentrations with microenvironment exposures to particulate matter (PM2.5), elemental and organic carbon, and between 1&2-AN and 1-AP with urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG). There was an association between work week mean PM2.5 levels and post-shift 1 & 2-AN, [141.8 pg/ml increase (95% CI:53.3, 230.2) for each IQR increase (5.54 µg/m3) in PM2.5,] but no associations with other exposure measures. There was a statistically significant increase in 8-OHdG concentrations with 1 & 2-AN (2.38 µg/mg creatinine (95%CI: 0.19, 4.58) per 242.85 pg/mg creatinine increase in 1 & 2-AN), and suggestive associations with all other exposure measures. Our findings suggest associations between urinary amino-PAHs with vehicle exhaust related PM2.5 as well as with a biomarker of oxidative DNA damage.

Duke Scholars

Published In

Toxics

DOI

EISSN

2305-6304

ISSN

2305-6304

Publication Date

September 2014

Volume

2

Issue

3

Start / End Page

377 / 390
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Neophytou, A. M., Hart, J. E., Chang, Y., Zhang, J. J., Smith, T. J., Garshick, E., & Laden, F. (2014). Short-term traffic related exposures and biomarkers of nitro-PAH exposure and oxidative DNA damage. Toxics, 2(3), 377–390. https://doi.org/10.3390/toxics2030377
Neophytou, Andreas M., Jaime E. Hart, Yan Chang, Junfeng Jim Zhang, Thomas J. Smith, Eric Garshick, and Francine Laden. “Short-term traffic related exposures and biomarkers of nitro-PAH exposure and oxidative DNA damage.Toxics 2, no. 3 (September 2014): 377–90. https://doi.org/10.3390/toxics2030377.
Neophytou AM, Hart JE, Chang Y, Zhang JJ, Smith TJ, Garshick E, et al. Short-term traffic related exposures and biomarkers of nitro-PAH exposure and oxidative DNA damage. Toxics. 2014 Sep;2(3):377–90.
Neophytou, Andreas M., et al. “Short-term traffic related exposures and biomarkers of nitro-PAH exposure and oxidative DNA damage.Toxics, vol. 2, no. 3, Sept. 2014, pp. 377–90. Epmc, doi:10.3390/toxics2030377.
Neophytou AM, Hart JE, Chang Y, Zhang JJ, Smith TJ, Garshick E, Laden F. Short-term traffic related exposures and biomarkers of nitro-PAH exposure and oxidative DNA damage. Toxics. 2014 Sep;2(3):377–390.

Published In

Toxics

DOI

EISSN

2305-6304

ISSN

2305-6304

Publication Date

September 2014

Volume

2

Issue

3

Start / End Page

377 / 390