Short-term traffic related exposures and biomarkers of nitro-PAH exposure and oxidative DNA damage.

Published

Journal Article

Exposure to vehicle exhaust has been associated with cardiac and respiratory disease, lung cancer, and greater overall mortality. We investigated whether amino- polycyclic aromatic hydrocarbon (amino-PAH) metabolites of nitro-PAHs could be used as biomarkers of these exposures. Pre- and post-shift urine samples were collected at the beginning and end of a work week from 82 male U.S trucking industry workers. We used repeated-measures analysis to examine associations of total 1- and 2-aminonaphthalene (1 & 2-AN) and 1-aminopyrene (1-AP) urinary concentrations with microenvironment exposures to particulate matter (PM2.5), elemental and organic carbon, and between 1&2-AN and 1-AP with urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG). There was an association between work week mean PM2.5 levels and post-shift 1 & 2-AN, [141.8 pg/ml increase (95% CI:53.3, 230.2) for each IQR increase (5.54 µg/m3) in PM2.5,] but no associations with other exposure measures. There was a statistically significant increase in 8-OHdG concentrations with 1 & 2-AN (2.38 µg/mg creatinine (95%CI: 0.19, 4.58) per 242.85 pg/mg creatinine increase in 1 & 2-AN), and suggestive associations with all other exposure measures. Our findings suggest associations between urinary amino-PAHs with vehicle exhaust related PM2.5 as well as with a biomarker of oxidative DNA damage.

Full Text

Duke Authors

Cited Authors

  • Neophytou, AM; Hart, JE; Chang, Y; Zhang, JJ; Smith, TJ; Garshick, E; Laden, F

Published Date

  • September 2014

Published In

Volume / Issue

  • 2 / 3

Start / End Page

  • 377 - 390

PubMed ID

  • 25254201

Pubmed Central ID

  • 25254201

Electronic International Standard Serial Number (EISSN)

  • 2305-6304

International Standard Serial Number (ISSN)

  • 2305-6304

Digital Object Identifier (DOI)

  • 10.3390/toxics2030377

Language

  • eng