Memory T cells in organ transplantation: progress and challenges.

Published

Journal Article (Review)

Antigen-experienced T cells, also known as memory T cells, are functionally and phenotypically distinct from naive T cells. Their enhanced expression of adhesion molecules and reduced requirement for co-stimulation enables them to mount potent and rapid recall responses to subsequent antigen encounters. Memory T cells generated in response to prior antigen exposures can cross-react with other nonidentical, but similar, antigens. This heterologous cross-reactivity not only enhances protective immune responses, but also engenders de novo alloimmunity. This latter characteristic is increasingly recognized as a potential barrier to allograft acceptance that is worthy of immunotherapeutic intervention, and several approaches have been investigated. Calcineurin inhibition effectively controls memory T-cell responses to allografts, but this benefit comes at the expense of increased infectious morbidity. Lymphocyte depletion eliminates allospecific T cells but spares memory T cells to some extent, such that patients do not completely lose protective immunity. Co-stimulation blockade is associated with reduced adverse-effect profiles and improved graft function relative to calcineurin inhibition, but lacks efficacy in controlling memory T-cell responses. Targeting the adhesion molecules that are upregulated on memory T cells might offer additional means to control co-stimulation-blockade-resistant memory T-cell responses.

Full Text

Duke Authors

Cited Authors

  • Espinosa, JR; Samy, KP; Kirk, AD

Published Date

  • June 2016

Published In

Volume / Issue

  • 12 / 6

Start / End Page

  • 339 - 347

PubMed ID

  • 26923209

Pubmed Central ID

  • 26923209

Electronic International Standard Serial Number (EISSN)

  • 1759-507X

Digital Object Identifier (DOI)

  • 10.1038/nrneph.2016.9

Language

  • eng

Conference Location

  • England