A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.

Published online

Journal Article

Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-γ, tumor necrosis factor-α, interleukin-6, and others). The host genomic response to influenza infection is robust and may provide the means for early detection, more timely therapeutic interventions, a meaningful reduction in clinical disease, and an effective molecular means to track response to therapy.

Full Text

Duke Authors

Cited Authors

  • McClain, MT; Nicholson, BP; Park, LP; Liu, T-Y; Hero, AO; Tsalik, EL; Zaas, AK; Veldman, T; Hudson, LL; Lambkin-Williams, R; Gilbert, A; Burke, T; Nichols, M; Ginsburg, GS; Woods, CW

Published Date

  • January 2016

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • ofw007 -

PubMed ID

  • 26933666

Pubmed Central ID

  • 26933666

International Standard Serial Number (ISSN)

  • 2328-8957

Digital Object Identifier (DOI)

  • 10.1093/ofid/ofw007

Language

  • eng

Conference Location

  • United States