HIV-Host Interactions: Implications for Vaccine Design.
Journal Article (Journal Article;Review)
Development of an effective AIDS vaccine is a global priority. However, the extreme diversity of HIV type 1 (HIV-1), which is a consequence of its propensity to mutate to escape immune responses, along with host factors that prevent the elicitation of protective immune responses, continue to hinder vaccine development. Breakthroughs in understanding of the biology of the transmitted virus, the structure and nature of its envelope trimer, vaccine-induced CD8 T cell control in primates, and host control of broadly neutralizing antibody elicitation have given rise to new vaccine strategies. Despite this promise, emerging data from preclinical trials reinforce the need for additional insight into virus-host biology in order to facilitate the development of a successful vaccine.
Full Text
Duke Authors
Cited Authors
- Haynes, BF; Shaw, GM; Korber, B; Kelsoe, G; Sodroski, J; Hahn, BH; Borrow, P; McMichael, AJ
Published Date
- March 9, 2016
Published In
Volume / Issue
- 19 / 3
Start / End Page
- 292 - 303
PubMed ID
- 26922989
Pubmed Central ID
- PMC4823811
Electronic International Standard Serial Number (EISSN)
- 1934-6069
Digital Object Identifier (DOI)
- 10.1016/j.chom.2016.02.002
Language
- eng
Conference Location
- United States