HIV-Host Interactions: Implications for Vaccine Design.

Published

Journal Article (Review)

Development of an effective AIDS vaccine is a global priority. However, the extreme diversity of HIV type 1 (HIV-1), which is a consequence of its propensity to mutate to escape immune responses, along with host factors that prevent the elicitation of protective immune responses, continue to hinder vaccine development. Breakthroughs in understanding of the biology of the transmitted virus, the structure and nature of its envelope trimer, vaccine-induced CD8 T cell control in primates, and host control of broadly neutralizing antibody elicitation have given rise to new vaccine strategies. Despite this promise, emerging data from preclinical trials reinforce the need for additional insight into virus-host biology in order to facilitate the development of a successful vaccine.

Full Text

Duke Authors

Cited Authors

  • Haynes, BF; Shaw, GM; Korber, B; Kelsoe, G; Sodroski, J; Hahn, BH; Borrow, P; McMichael, AJ

Published Date

  • March 2016

Published In

Volume / Issue

  • 19 / 3

Start / End Page

  • 292 - 303

PubMed ID

  • 26922989

Pubmed Central ID

  • 26922989

Electronic International Standard Serial Number (EISSN)

  • 1934-6069

International Standard Serial Number (ISSN)

  • 1931-3128

Digital Object Identifier (DOI)

  • 10.1016/j.chom.2016.02.002

Language

  • eng