The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium.

Journal Article (Journal Article)

Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity of tumor subtypes, and retrospective exposure assessment. Here, we briefly describe the Glioma International Case-Control (GICC) Study (recruitment, 2010-2013), a study being conducted by the Genetic Epidemiology of Glioma International Consortium that integrates data from multiple data collection sites, uses a common protocol and questionnaire, and includes biospecimen collection. To our knowledge, the GICC Study is the largest glioma study to date that includes collection of blood samples, which will allow for genetic analysis and interrogation of gene-environment interactions.

Full Text

Duke Authors

Cited Authors

  • Amirian, ES; Armstrong, GN; Zhou, R; Lau, CC; Claus, EB; Barnholtz-Sloan, JS; Il'yasova, D; Schildkraut, J; Ali-Osman, F; Sadetzki, S; Johansen, C; Houlston, RS; Jenkins, RB; Lachance, D; Olson, SH; Bernstein, JL; Merrell, RT; Wrensch, MR; Davis, FG; Lai, R; Shete, S; Amos, CI; Scheurer, ME; Aldape, K; Alafuzoff, I; Brännström, T; Broholm, H; Collins, P; Giannini, C; Rosenblum, M; Tihan, T; Melin, BS; Bondy, ML

Published Date

  • January 15, 2016

Published In

Volume / Issue

  • 183 / 2

Start / End Page

  • 85 - 91

PubMed ID

  • 26656478

Pubmed Central ID

  • PMC4706682

Electronic International Standard Serial Number (EISSN)

  • 1476-6256

Digital Object Identifier (DOI)

  • 10.1093/aje/kwv235


  • eng

Conference Location

  • United States