Roles of Autophagy and Autophagy-Related Proteins in Antifungal Immunity.

Journal Article (Journal Article;Review)

Autophagy was initially characterized as a process to digest cellular components, including damaged cell organelles or unused proteins. However, later studies showed that autophagy plays an important role to protect hosts from microbial infections. Accumulating evidences showed the contribution of autophagy itself and autophagy-related proteins (ATGs) in the clearance of bacteria, virus, and parasites. A number of studies also revealed the molecular mechanisms by which autophagy is initiated and developed. Furthermore, it is now understood that some ATGs are shared between two distinct processes; autophagy and LC3-associated phagocytosis (LAP). Thus, our understanding on autophagy has been greatly enhanced in the last decade. By contrast, roles of autophagy and ATGs in fungal infections are still elusive relative to those in bacterial and viral infections. Based on limited numbers of reports, ATG-mediated host responses appear to significantly vary depending on invading fungal species. In this review, we discuss how autophagy and ATGs are involved in antifungal immune responses based on recent discoveries.

Full Text

Duke Authors

Cited Authors

  • Kanayama, M; Shinohara, ML

Published Date

  • 2016

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 47 -

PubMed ID

  • 26925060

Pubmed Central ID

  • PMC4757664

International Standard Serial Number (ISSN)

  • 1664-3224

Digital Object Identifier (DOI)

  • 10.3389/fimmu.2016.00047


  • eng

Conference Location

  • Switzerland