Challenges in identifying Lennox-Gastaut syndrome in adults: A case series illustrating its changing nature.

Published online

Journal Article

The variable presentation and progression of Lennox-Gastaut syndrome (LGS) can make it difficult to recognize, particularly in adults. To improve diagnosis, a retrospective chart review was conducted on patients who were diagnosed as adults and/or were followed for several years after diagnosis. We present 5 cases that illustrate changes in LGS features over time. Cases 1 and 2 were diagnosed by age 8 with intractable seizures, developmental delay, and abnormal EEGs with 1.5-2 Hz SSW discharges. However, seizure type and frequency changed over time for both patients, and the incidence of SSW discharges decreased. Cases 3, 4, and 5 were diagnosed with LGS as adults based on current and past features and symptoms, including treatment-resistant seizures, cognitive and motor impairment, and abnormal EEG findings. While incomplete, their records indicate that an earlier LGS diagnosis may have been missed or lost to history. These cases demonstrate the need to thoroughly and continuously evaluate all aspects of a patient's encephalopathy, bearing in mind the potential for LGS features to change over time.

Full Text

Duke Authors

Cited Authors

  • Piña-Garza, JE; Chung, S; Montouris, GD; Radtke, RA; Resnick, T; Wechsler, RT

Published Date

  • 2016

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 38 - 43

PubMed ID

  • 26977407

Pubmed Central ID

  • 26977407

International Standard Serial Number (ISSN)

  • 2213-3232

Digital Object Identifier (DOI)

  • 10.1016/j.ebcr.2016.01.004

Language

  • eng

Conference Location

  • United States