Initial experience with the use of foetal/neonatal bovine acellular dermal collagen matrix (SurgiMend™) for tissue-expander breast reconstruction.


Journal Article

BACKGROUND: Acellular dermal matrix (ADM) is commonly used in staged breast reconstruction using tissue expanders (TEs). The literature on human ADM has reported variable outcomes, and there is a paucity of data for xenogenic sources of ADM. The aim of this study is to evaluate the early complications, risk factors and outcomes using SurgiMend™ in staged breast reconstruction. METHODS: An Institutional Review Board (IRB)-approved, retrospective analysis of a single surgeon's experience was performed. From August 2009 to May 2011, 65 patients underwent staged breast reconstruction using 95 sheets of SurgiMend™. The nominal TE fill volume was 383 ± 83 cc (range 250-550), mean intra-operative fill volume was 148 ± 86 cc (range 0-350) and mean final fill volume was 413 ± 176 cc (range 100-800). The mean clinic follow-up time was 16.9 ± 8.7 months; mean age was 50.9 ± 11.7 years; and average body mass index (BMI) was 26.0 ± 5.5 kg m(-2). Correlation with risk factors and clinical outcomes were analysed. RESULTS: The incidences of postoperative complications were: haematoma 3.2%, seroma 7.5% and re-operation due to infection 2.1%. Age, diabetes mellitus, and hypertension had a significant correlation with an increased overall complication rate. With respect to early complications, such as infection requiring re-operation, diabetes demonstrated a trend with an odds ratio of 11.69. CONCLUSION: This study demonstrates that the use of SurgiMend™ is associated with low early complication rates and is well tolerated in staged breast reconstruction.

Full Text

Cited Authors

  • Ohkuma, R; Buretta, KJ; Mohan, R; Rosson, GD; Rad, AN

Published Date

  • September 2013

Published In

Volume / Issue

  • 66 / 9

Start / End Page

  • 1195 - 1201

PubMed ID

  • 23768943

Pubmed Central ID

  • 23768943

Electronic International Standard Serial Number (EISSN)

  • 1878-0539

International Standard Serial Number (ISSN)

  • 1748-6815

Digital Object Identifier (DOI)

  • 10.1016/j.bjps.2013.05.004


  • eng