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Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening

Publication ,  Journal Article
Zhang, L; Ren, J; Pan, KF; Ma, JL; Li, JY; Shen, L; Zhang, XD; Li, J; Fan, DM; Gail, M; You, WC
Published in: International Journal of Cancer
2010

To evaluate gastric carcinoma-associated antigen, MG7-Ag, for detection of gastric cancer in a high-risk population, a population-based screening of gastric cancer was conducted in Linqu County, Shandong Province, China. In 2002 and 2003, a total of 2,710 participants aged 35-65 years received an endoscopic examination with 5 biopsies taken from standard sites with pathological diagnosis, and serum samples were collected to detect MG7-Ag by serum-based Immunopolymerase chain reaction (PCR) assay. The sensitivity and specificity of MG7-Ag Immuno-PCR assay in detecting of gastric cancer were assessed. Of 2,710 participants, 148 (5.46%) were determined to be MG7-Ag positive. The sensitivity of MG7-Ag Immuno-PCR assay for the detection of gastric cancer was 77.5% (31 of 40 gastric cancer cases), the specificity was 95.62% (2,553 of 2,670 nongastric cancer subjects) and the accuracy was 73.12%. A total of 24 gastric cancer cases were in Stage I or II, of which 17 (70.8%) were MG7-Ag positive. However, the proportion of MG7-Ag positivity in subjects with superficial gastritis, chronic atrophic gastritis, intestinal metaplasia, indefinite dysplasia or dysplasia was ranged from 3.00% to 5.61% in comparison with 77.5% in those with gastric cancer. Our findings suggest that MG7-Ag was a sensitive and specific serum biomarker and may have a potential for gastric cancer screening in the high-risk population.

Duke Scholars

Published In

International Journal of Cancer

DOI

ISSN

0020-7136

Publication Date

2010

Volume

126

Start / End Page

469 / 473

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
Chicago
ICMJE
MLA
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Zhang, L., Ren, J., Pan, K. F., Ma, J. L., Li, J. Y., Shen, L., … You, W. C. (2010). Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening. International Journal of Cancer, 126, 469–473. https://doi.org/10.1002/ijc.24739
Zhang, L., J. Ren, K. F. Pan, J. L. Ma, J. Y. Li, L. Shen, X. D. Zhang, et al. “Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening.” International Journal of Cancer 126 (2010): 469–73. https://doi.org/10.1002/ijc.24739.
Zhang L, Ren J, Pan KF, Ma JL, Li JY, Shen L, et al. Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening. International Journal of Cancer. 2010;126:469–73.
Zhang, L., et al. “Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening.” International Journal of Cancer, vol. 126, 2010, pp. 469–73. Manual, doi:10.1002/ijc.24739.
Zhang L, Ren J, Pan KF, Ma JL, Li JY, Shen L, Zhang XD, Li J, Fan DM, Gail M, You WC. Detection of gastric carcinoma-associated MG7-Ag by serum immuno-PCR assay in a high-risk Chinese population, with implication for screening. International Journal of Cancer. 2010;126:469–473.
Journal cover image

Published In

International Journal of Cancer

DOI

ISSN

0020-7136

Publication Date

2010

Volume

126

Start / End Page

469 / 473

Related Subject Headings

  • Oncology & Carcinogenesis
  • 3211 Oncology and carcinogenesis
  • 1112 Oncology and Carcinogenesis