History of chickenpox in glioma risk: a report from the glioma international case-control study (GICC).

Journal Article (Journal Article;Multicenter Study)

Varicella zoster virus (VZV) is a neurotropic α-herpesvirus that causes chickenpox and establishes life-long latency in the cranial nerve and dorsal root ganglia of the host. To date, VZV is the only virus consistently reported to have an inverse association with glioma. The Glioma International Case-Control Study (GICC) is a large, multisite consortium with data on 4533 cases and 4171 controls collected across five countries. Here, we utilized the GICC data to confirm the previously reported associations between history of chickenpox and glioma risk in one of the largest studies to date on this topic. Using two-stage random-effects restricted maximum likelihood modeling, we found that a positive history of chickenpox was associated with a 21% lower glioma risk, adjusting for age and sex (95% confidence intervals (CI): 0.65-0.96). Furthermore, the protective effect of chickenpox was stronger for high-grade gliomas. Our study provides additional evidence that the observed protective effect of chickenpox against glioma is unlikely to be coincidental. Future studies, including meta-analyses of the literature and investigations of the potential biological mechanism, are warranted.

Full Text

Duke Authors

Cited Authors

  • Amirian, ES; Scheurer, ME; Zhou, R; Wrensch, MR; Armstrong, GN; Lachance, D; Olson, SH; Lau, CC; Claus, EB; Barnholtz-Sloan, JS; Il'yasova, D; Schildkraut, J; Ali-Osman, F; Sadetzki, S; Jenkins, RB; Bernstein, JL; Merrell, RT; Davis, FG; Lai, R; Shete, S; Amos, CI; Melin, BS; Bondy, ML

Published Date

  • June 2016

Published In

Volume / Issue

  • 5 / 6

Start / End Page

  • 1352 - 1358

PubMed ID

  • 26972449

Pubmed Central ID

  • PMC4924393

Electronic International Standard Serial Number (EISSN)

  • 2045-7634

Digital Object Identifier (DOI)

  • 10.1002/cam4.682


  • eng

Conference Location

  • United States