Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.
Journal Article (Journal Article)
Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
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Duke Authors
Cited Authors
- Galloway-Peña, J; Clement, ME; Sharma Kuinkel, BK; Ruffin, F; Flores, AR; Levinson, H; Shelburne, SA; Moore, Z; Fowler, VG
Published Date
- January 2016
Published In
Volume / Issue
- 3 / 1
Start / End Page
- ofw042 -
PubMed ID
- 27006966
Pubmed Central ID
- PMC4800461
International Standard Serial Number (ISSN)
- 2328-8957
Digital Object Identifier (DOI)
- 10.1093/ofid/ofw042
Language
- eng
Conference Location
- United States