Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.

Journal Article (Journal Article)

Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.

Full Text

Duke Authors

Cited Authors

  • Galloway-Peña, J; Clement, ME; Sharma Kuinkel, BK; Ruffin, F; Flores, AR; Levinson, H; Shelburne, SA; Moore, Z; Fowler, VG

Published Date

  • January 2016

Published In

Volume / Issue

  • 3 / 1

Start / End Page

  • ofw042 -

PubMed ID

  • 27006966

Pubmed Central ID

  • PMC4800461

International Standard Serial Number (ISSN)

  • 2328-8957

Digital Object Identifier (DOI)

  • 10.1093/ofid/ofw042


  • eng

Conference Location

  • United States