Application of Whole-Genome Sequencing to an Unusual Outbreak of Invasive Group A Streptococcal Disease.
Whole-genome analysis was applied to investigate atypical point-source transmission of 2 invasive group A streptococcal (GAS) infections. Isolates were serotype M4, ST39, and genetically indistinguishable. Comparison with MGAS10750 revealed nonsynonymous polymorphisms in ropB and increased speB transcription. This study demonstrates the usefulness of whole-genome analyses for GAS outbreaks.
Galloway-Peña, J; Clement, ME; Sharma Kuinkel, BK; Ruffin, F; Flores, AR; Levinson, H; Shelburne, SA; Moore, Z; Fowler, VG
Volume / Issue
Start / End Page
Pubmed Central ID
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)