Lifestyle factors and health-related quality of life in bladder cancer survivors: a systematic review.

Journal Article (Journal Article;Review;Systematic Review)

PURPOSE: Diet, physical activity, and smoking cessation are modifiable lifestyle factors that have been shown to improve health-related quality of life (HRQOL) in many cancer survivors. Our objective was to systematically review the literature on the associations between lifestyle factors, namely diet, physical activity, smoking status, and HRQOL in bladder cancer survivors. METHODS: We queried PubMed, EMBASE, and Cochrane libraries. Two reviewers reviewed abstracts independently, and a third reviewer arbitrated disagreements. A descriptive analysis was performed. Quality assessment was conducted using the Newcastle-Ottawa Quality Assessment Scale for observational studies and the Cochrane Risk of Bias Tool for clinical trials. RESULTS: We identified 1167 publications in the initial search, of which 9 met inclusion criteria for full-text review. We were able to obtain data on the outcomes of interest for 5 publications. A total of 1288 patients who underwent treatment for bladder cancer were included. Three studies were observational by design and two were randomized controlled trials. Physical activity was addressed by 4 studies, smoking status by 2 studies, and diet by 1 study. CONCLUSIONS: The review highlights the limited evidence around lifestyle factors and quality of life in bladder cancer survivors. There is some evidence for a positive association between HRQOL and physical activity, but insufficient evidence upon which to draw conclusions about the effects of consuming fruits and vegetables or non-smoking. IMPLICATIONS FOR CANCER SURVIVORS: There is limited evidence to support a positive association between health-related quality of life and physical activity, but insufficient evidence upon which to base any conclusions about consumption of fruits and vegetables or smoking cessation in bladder cancer survivors.

Full Text

Duke Authors

Cited Authors

  • Gopalakrishna, A; Longo, TA; Fantony, JJ; Van Noord, M; Inman, BA

Published Date

  • October 2016

Published In

Volume / Issue

  • 10 / 5

Start / End Page

  • 874 - 882

PubMed ID

  • 27002077

Pubmed Central ID

  • PMC5018420

Electronic International Standard Serial Number (EISSN)

  • 1932-2267

Digital Object Identifier (DOI)

  • 10.1007/s11764-016-0533-8


  • eng

Conference Location

  • United States