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Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.

Publication ,  Journal Article
Gundlund, A; Fosbøl, EL; Kim, S; Fonarow, GC; Gersh, BJ; Kowey, PR; Hylek, E; Mahaffey, KW; Thomas, L; Piccini, JP; Peterson, ED ...
Published in: Am Heart J
May 2016

BACKGROUND: We addressed whether patients with a family history of atrial fibrillation (AF) were diagnosed as having AF earlier in life, were more symptomatic, and had worse outcomes compared with those without a family history of AF. METHODS: Using the ORBIT-AF, we compared symptoms and disease characteristics in those with and without a family history of AF. A family history of AF was defined as AF in a first-degree family member and obtained by patient self-reporting. Multivariable Cox proportional hazard analyses were performed to compare the incidence of cardiovascular outcomes, AF progression, all-cause hospitalization, and all-cause death. RESULTS: Among 9,999 patients with AF from 176 US outpatient clinics, 1,481 (14.8%) had a family history of AF. Relative to those without, those with a family history of AF developed AF 5 years earlier on average (median age 65 vs 70 years, P < .01), with less comorbidity, and had more severe AF-related symptoms. No differences were found between the 2 groups in the risk of AF progression (adjusted hazard ratio [HR] 0.98, 95% CI 0.85-1.14), stroke, non-central nervous system embolism, or transient ischemic attack (adjusted HR 0.95, 95% CI 0.67-1.34), all-cause hospitalization (adjusted HR 1.03, 95% CI 0.94-1.12), and all-cause death (adjusted HR 1.05, 95% CI 0.86-1.27). CONCLUSIONS: Patients with a family history of AF developed AF at a younger age, had less comorbidity, and were more symptomatic. Once AF developed, no significantly increased risks of AF progression and thromboembolism were associated with a family history of AF compared with no family history.

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Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2016

Volume

175

Start / End Page

28 / 35

Location

United States

Related Subject Headings

  • Thromboembolism
  • Symptom Assessment
  • Risk Factors
  • Registries
  • Proportional Hazards Models
  • Outpatients
  • Middle Aged
  • Medical History Taking
  • Male
  • Incidence
 

Citation

APA
Chicago
ICMJE
MLA
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Gundlund, A., Fosbøl, E. L., Kim, S., Fonarow, G. C., Gersh, B. J., Kowey, P. R., … ORBIT-AF Investigators, . (2016). Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry. Am Heart J, 175, 28–35. https://doi.org/10.1016/j.ahj.2016.01.020
Gundlund, Anna, Emil Loldrup Fosbøl, Sunghee Kim, Gregg C. Fonarow, Bernard J. Gersh, Peter R. Kowey, Elaine Hylek, et al. “Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry.Am Heart J 175 (May 2016): 28–35. https://doi.org/10.1016/j.ahj.2016.01.020.
Gundlund A, Fosbøl EL, Kim S, Fonarow GC, Gersh BJ, Kowey PR, Hylek E, Mahaffey KW, Thomas L, Piccini JP, Peterson ED, ORBIT-AF Investigators. Family history of atrial fibrillation is associated with earlier-onset and more symptomatic atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation (ORBIT-AF) registry. Am Heart J. 2016 May;175:28–35.
Journal cover image

Published In

Am Heart J

DOI

EISSN

1097-6744

Publication Date

May 2016

Volume

175

Start / End Page

28 / 35

Location

United States

Related Subject Headings

  • Thromboembolism
  • Symptom Assessment
  • Risk Factors
  • Registries
  • Proportional Hazards Models
  • Outpatients
  • Middle Aged
  • Medical History Taking
  • Male
  • Incidence