Preoperative partial breast


Book Section

© Springer International Publishing Switzerland, 2016. Partial breast irradiation, treatment focused only on the surgical bed plus a variable margin, has evolved as an ultra-convenient alternative to whole breast irradiation for selected patients with early-stage breast cancer. A number of techniques are available for treatment delivery, ranging from a single intraoperative treatment to one week of twice daily treatments postoperatively. However, concerns of suboptimal cosmetic outcomes have been raised with the highly accessible external-beam technique and linked to large postoperative target volumes. Preoperative radiation, delivered prior to surgical resection, is under investigation as an alternative approach utilizing in situ targeting of a small intact breast tumor to identify the highest-risk regions and reduce the volume of uninvolved breast tissue receiving high radiation doses. Several commonly utilized technologies can be used to deliver preoperative radiation and early efficacy and toxicity reports for this treatment approach are promising. The rationale, treatment delivery techniques, available outcomes data, and ongoing investigations for preoperative partial breast irradiation are described in further depth in the accompanying chapter.

Full Text

Duke Authors

Cited Authors

  • Mowery, YM; Yu, CX; Horton, JK

Published Date

  • January 1, 2015

Book Title

  • Short Course Breast Radiotherapy: A Comprehensive Review of Hypofractionation, Partial Breast, and Intra-Operative Irradiation

Start / End Page

  • 415 - 440

International Standard Book Number 13 (ISBN-13)

  • 9783319243863

Digital Object Identifier (DOI)

  • 10.1007/978-3-319-24388-7_27

Citation Source

  • Scopus