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Update on pulmonary disease due to non-tuberculous mycobacteria.

Publication ,  Journal Article
Stout, JE; Koh, W-J; Yew, WW
Published in: Int J Infect Dis
April 2016

Non-tuberculous mycobacteria (NTM) are emerging worldwide as significant causes of chronic pulmonary infection, posing a number of challenges for both clinicians and researchers. While a number of studies worldwide have described an increasing prevalence of NTM pulmonary disease over time, population-based data are relatively sparse and subject to ascertainment bias. Furthermore, the disease is geographically heterogeneous. While some species are commonly implicated worldwide (Mycobacterium avium complex, Mycobacterium abscessus), others (e.g., Mycobacterium malmoense, Mycobacterium xenopi) are regionally important. Thoracic computed tomography, microbiological testing with identification to the species level, and local epidemiology must all be taken into account to accurately diagnose NTM pulmonary disease. A diagnosis of NTM pulmonary disease does not necessarily imply that treatment is required; a patient-centered approach is essential. When treatment is required, multidrug therapy based on appropriate susceptibility testing for the species in question should be used. New diagnostic and therapeutic modalities are needed to optimize the management of these complicated infections.

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Published In

Int J Infect Dis

DOI

EISSN

1878-3511

Publication Date

April 2016

Volume

45

Start / End Page

123 / 134

Location

Canada

Related Subject Headings

  • Respiratory Tract Infections
  • Mycobacterium Infections, Nontuberculous
  • Microbiology
  • Lung Diseases
  • Humans
  • Disease Susceptibility
  • 4206 Public health
  • 4202 Epidemiology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services
 

Citation

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ICMJE
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Stout, J. E., Koh, W.-J., & Yew, W. W. (2016). Update on pulmonary disease due to non-tuberculous mycobacteria. Int J Infect Dis, 45, 123–134. https://doi.org/10.1016/j.ijid.2016.03.006
Stout, Jason E., Won-Jung Koh, and Wing Wai Yew. “Update on pulmonary disease due to non-tuberculous mycobacteria.Int J Infect Dis 45 (April 2016): 123–34. https://doi.org/10.1016/j.ijid.2016.03.006.
Stout JE, Koh W-J, Yew WW. Update on pulmonary disease due to non-tuberculous mycobacteria. Int J Infect Dis. 2016 Apr;45:123–34.
Stout, Jason E., et al. “Update on pulmonary disease due to non-tuberculous mycobacteria.Int J Infect Dis, vol. 45, Apr. 2016, pp. 123–34. Pubmed, doi:10.1016/j.ijid.2016.03.006.
Stout JE, Koh W-J, Yew WW. Update on pulmonary disease due to non-tuberculous mycobacteria. Int J Infect Dis. 2016 Apr;45:123–134.

Published In

Int J Infect Dis

DOI

EISSN

1878-3511

Publication Date

April 2016

Volume

45

Start / End Page

123 / 134

Location

Canada

Related Subject Headings

  • Respiratory Tract Infections
  • Mycobacterium Infections, Nontuberculous
  • Microbiology
  • Lung Diseases
  • Humans
  • Disease Susceptibility
  • 4206 Public health
  • 4202 Epidemiology
  • 3202 Clinical sciences
  • 1117 Public Health and Health Services