Update on pulmonary disease due to non-tuberculous mycobacteria.


Journal Article (Review)

Non-tuberculous mycobacteria (NTM) are emerging worldwide as significant causes of chronic pulmonary infection, posing a number of challenges for both clinicians and researchers. While a number of studies worldwide have described an increasing prevalence of NTM pulmonary disease over time, population-based data are relatively sparse and subject to ascertainment bias. Furthermore, the disease is geographically heterogeneous. While some species are commonly implicated worldwide (Mycobacterium avium complex, Mycobacterium abscessus), others (e.g., Mycobacterium malmoense, Mycobacterium xenopi) are regionally important. Thoracic computed tomography, microbiological testing with identification to the species level, and local epidemiology must all be taken into account to accurately diagnose NTM pulmonary disease. A diagnosis of NTM pulmonary disease does not necessarily imply that treatment is required; a patient-centered approach is essential. When treatment is required, multidrug therapy based on appropriate susceptibility testing for the species in question should be used. New diagnostic and therapeutic modalities are needed to optimize the management of these complicated infections.

Full Text

Duke Authors

Cited Authors

  • Stout, JE; Koh, W-J; Yew, WW

Published Date

  • April 2016

Published In

Volume / Issue

  • 45 /

Start / End Page

  • 123 - 134

PubMed ID

  • 26976549

Pubmed Central ID

  • 26976549

Electronic International Standard Serial Number (EISSN)

  • 1878-3511

Digital Object Identifier (DOI)

  • 10.1016/j.ijid.2016.03.006


  • eng

Conference Location

  • Canada