Striatonigral control of movement velocity in mice.

Published

Journal Article

The basal ganglia have long been implicated in action initiation. Using three-dimensional motion capture, we quantified the effects of optogenetic stimulation of the striatonigral (direct) pathway on movement kinematics. We generated transgenic mice with channelrhodopsin-2 expression in striatal neurons that express the D1-like dopamine receptor. With optic fibres placed in the sensorimotor striatum, an area known to contain movement velocity-related single units, photo-stimulation reliably produced movements that could be precisely quantified with our motion capture programme. A single light pulse was sufficient to elicit movements with short latencies (< 30 ms). Increasing stimulation frequency increased movement speed, with a highly linear relationship. These findings support the hypothesis that the sensorimotor striatum is part of a velocity controller that controls rate of change in body configurations.

Full Text

Duke Authors

Cited Authors

  • Bartholomew, RA; Li, H; Gaidis, EJ; Stackmann, M; Shoemaker, CT; Rossi, MA; Yin, HH

Published Date

  • April 2016

Published In

Volume / Issue

  • 43 / 8

Start / End Page

  • 1097 - 1110

PubMed ID

  • 27091436

Pubmed Central ID

  • 27091436

Electronic International Standard Serial Number (EISSN)

  • 1460-9568

International Standard Serial Number (ISSN)

  • 0953-816X

Digital Object Identifier (DOI)

  • 10.1111/ejn.13187

Language

  • eng