Scholars@Duke

Statin therapy reduces growth of abdominal aortic aneurysms.

Publication ,  Journal Article
Karrowni, W; Dughman, S; Hajj, GP; Miller, FJ
Published in: J Investig Med
December 2011
Published version (DOI) Link to item

BACKGROUND: The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs). METHODS: We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance. RESULTS: Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors. CONCLUSIONS: To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.

Duke Scholars

Francis Joseph Miller Jr.
Author Francis Joseph Miller Jr. Medicine, Cardiology

Published In

J Investig Med

DOI

10.2130/JIM.0b013e31823548e8

EISSN

1708-8267

Publication Date

December 2011

Volume

59

Issue

8

Start / End Page

1239 / 1243

Location

England

Related Subject Headings

  • Multivariate Analysis
  • Male
  • Linear Models
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • General Clinical Medicine
  • Female
  • Aortic Aneurysm, Abdominal
  • Aged
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Karrowni, W., Dughman, S., Hajj, G. P., & Miller, F. J. (2011). Statin therapy reduces growth of abdominal aortic aneurysms. J Investig Med, 59(8), 1239–1243. https://doi.org/10.2130/JIM.0b013e31823548e8
Karrowni, Wassef, Saadeddine Dughman, Georges P. Hajj, and Francis J. Miller. “Statin therapy reduces growth of abdominal aortic aneurysms.” J Investig Med 59, no. 8 (December 2011): 1239–43. https://doi.org/10.2130/JIM.0b013e31823548e8.
Karrowni W, Dughman S, Hajj GP, Miller FJ. Statin therapy reduces growth of abdominal aortic aneurysms. J Investig Med. 2011 Dec;59(8):1239–43.
Karrowni, Wassef, et al. “Statin therapy reduces growth of abdominal aortic aneurysms.” J Investig Med, vol. 59, no. 8, Dec. 2011, pp. 1239–43. Pubmed, doi:10.2130/JIM.0b013e31823548e8.
Karrowni W, Dughman S, Hajj GP, Miller FJ. Statin therapy reduces growth of abdominal aortic aneurysms. J Investig Med. 2011 Dec;59(8):1239–1243.

Published In

J Investig Med

DOI

10.2130/JIM.0b013e31823548e8

EISSN

1708-8267

Publication Date

December 2011

Volume

59

Issue

8

Start / End Page

1239 / 1243

Location

England

Related Subject Headings

  • Multivariate Analysis
  • Male
  • Linear Models
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Humans
  • General Clinical Medicine
  • Female
  • Aortic Aneurysm, Abdominal
  • Aged
  • 3202 Clinical sciences