Statin therapy reduces growth of abdominal aortic aneurysms.

Journal Article (Journal Article)

BACKGROUND: The aim of this study was to evaluate the influence of statins on the growth of small abdominal aortic aneurysms (AAAs). METHODS: We retrospectively examined AAA diameter in 211 patients who had undergone serial imaging surveillance. RESULTS: Patients treated with and without statins were similar regarding age, initial aneurysm size, diagnosis of diabetes and hypertension, and smoking history. Patients receiving statins had a decreased aneurysm growth rate compared with those patients not receiving statins (0.9 mm/y [interquartile range, -1.0 to +1.0] vs 3.2 mm/y [interquartile range, 2.0-4.9], P < 0.0001). This difference in the rate of growth was maintained after adjusting for potential confounding factors. CONCLUSIONS: To date, this is the one of the largest retrospective studies demonstrating an association between statin use and decreased growth rate of AAA.

Full Text

Duke Authors

Cited Authors

  • Karrowni, W; Dughman, S; Hajj, GP; Miller, FJ

Published Date

  • December 2011

Published In

Volume / Issue

  • 59 / 8

Start / End Page

  • 1239 - 1243

PubMed ID

  • 21997311

Pubmed Central ID

  • PMC3219796

Electronic International Standard Serial Number (EISSN)

  • 1708-8267

Digital Object Identifier (DOI)

  • 10.2130/JIM.0b013e31823548e8


  • eng

Conference Location

  • England