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Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys.

Publication ,  Journal Article
Lentz, SR; Miller, FJ; Piegors, DJ; Erger, RA; Fernández, JA; Griffin, JH; Heistad, DD
Published in: Circulation
August 13, 2002

BACKGROUND: Diet-induced atherosclerosis in monkeys produces abnormal anticoagulant responses to thrombin, including decreased generation of activated protein C (APC). We tested the hypothesis that anticoagulant responses to thrombin increase toward normal during regression of atherosclerosis. METHODS AND RESULTS: Six cynomolgus monkeys were fed a high-fat atherogenic diet for 44 months and then a low-fat regression diet for 8 months. Serum total cholesterol decreased from 417+/-44 to 68+/-6 mg/dL (mean+/-SEM) and LDL cholesterol decreased from 375+/-44 to 27+/-5 mg/dL after the regression diet. In response to infusion of thrombin, the activated partial thromboplastin time (APTT) increased by 11+/-3 seconds before the regression diet and by 41+/-22 seconds after the regression diet (P=0.01). The peak level of circulating plasma APC was 52+/-9 ng/mL before the regression diet and 88+/-17 ng/mL after the regression diet (P=0.01). The APC sensitivity of plasma factor V was identical before and after the regression diet. Three additional atherosclerotic monkeys that remained on the high-fat diet for 8 months demonstrated no change in APTT or activation of protein C in response to thrombin. CONCLUSIONS: Short-term dietary regression of atherosclerosis produces enhanced anticoagulant responses to thrombin in vivo.

Duke Scholars

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

August 13, 2002

Volume

106

Issue

7

Start / End Page

842 / 846

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasodilation
  • Thrombomodulin
  • Thrombin
  • Remission, Spontaneous
  • Protein C
  • Partial Thromboplastin Time
  • Macaca fascicularis
  • Lung
  • Lipids
 

Citation

APA
Chicago
ICMJE
MLA
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Lentz, S. R., Miller, F. J., Piegors, D. J., Erger, R. A., Fernández, J. A., Griffin, J. H., & Heistad, D. D. (2002). Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. Circulation, 106(7), 842–846. https://doi.org/10.1161/01.cir.0000024982.11646.25
Lentz, Steven R., Francis J. Miller, Donald J. Piegors, Rochelle A. Erger, José A. Fernández, John H. Griffin, and Donald D. Heistad. “Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys.Circulation 106, no. 7 (August 13, 2002): 842–46. https://doi.org/10.1161/01.cir.0000024982.11646.25.
Lentz SR, Miller FJ, Piegors DJ, Erger RA, Fernández JA, Griffin JH, et al. Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. Circulation. 2002 Aug 13;106(7):842–6.
Lentz, Steven R., et al. “Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys.Circulation, vol. 106, no. 7, Aug. 2002, pp. 842–46. Pubmed, doi:10.1161/01.cir.0000024982.11646.25.
Lentz SR, Miller FJ, Piegors DJ, Erger RA, Fernández JA, Griffin JH, Heistad DD. Anticoagulant responses to thrombin are enhanced during regression of atherosclerosis in monkeys. Circulation. 2002 Aug 13;106(7):842–846.

Published In

Circulation

DOI

EISSN

1524-4539

Publication Date

August 13, 2002

Volume

106

Issue

7

Start / End Page

842 / 846

Location

United States

Related Subject Headings

  • Vasodilator Agents
  • Vasodilation
  • Thrombomodulin
  • Thrombin
  • Remission, Spontaneous
  • Protein C
  • Partial Thromboplastin Time
  • Macaca fascicularis
  • Lung
  • Lipids