Depletion of myocardial high energy phosphates by induction of ventricular fibrillation prior to cardioplegic arrest.

Journal Article

The effects of a short period of ventricular fibrillation on myocardial high energy phosphates were assessed in two groups of rats. Group 1 underwent hypothermic crystalloid cardioplegia infusion and aortic cross-clamping. In Group 2, cardioplegia and cross-clamping were preceded by ten seconds of induced ventricular fibrillation. In rat hearts that had undergone ventricular fibrillation, adenosine triphosphate levels averaged only 70% (p less than .0001) and creatine phosphate levels averaged only 60% (p less than .0005) of levels measured following standard cardioplegic arrest without ventricular fibrillation. These findings are of potential importance in both routine cardiac surgical procedures and in organ procurement.

Duke Authors

Cited Authors

  • Levett, JM; Kadowaki, MH; Ip, JH; Karp, RB

Published Date

  • March 1, 1990

Published In

Volume / Issue

  • 31 / 2

Start / End Page

  • 209 - 212

PubMed ID

  • 2341480

Electronic International Standard Serial Number (EISSN)

  • 1827-191X

International Standard Serial Number (ISSN)

  • 0021-9509

Language

  • eng