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Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres.

Publication ,  Journal Article
Jain, A; Betancur, M; Patel, GD; Valmikinathan, CM; Mukhatyar, VJ; Vakharia, A; Pai, SB; Brahma, B; MacDonald, TJ; Bellamkonda, RV
Published in: Nature materials
March 2014

Glioblastoma multiforme is an aggressive, invasive brain tumour with a poor survival rate. Available treatments are ineffective and some tumours remain inoperable because of their size or location. The tumours are known to invade and migrate along white matter tracts and blood vessels. Here, we exploit this characteristic of glioblastoma multiforme by engineering aligned polycaprolactone (PCL)-based nanofibres for tumour cells to invade and, hence, guide cells away from the primary tumour site to an extracortical location. This extracortial sink is a cyclopamine drug-conjugated, collagen-based hydrogel. When aligned PCL-nanofibre films in a PCL/polyurethane carrier conduit were inserted in the vicinity of an intracortical human U87MG glioblastoma xenograft, a significant number of human glioblastoma cells migrated along the aligned nanofibre films and underwent apoptosis in the extracortical hydrogel. Tumour volume in the brain was significantly lower following insertion of aligned nanofibre implants compared with the application of smooth fibres or no implants.

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Published In

Nature materials

DOI

EISSN

1476-4660

ISSN

1476-1122

Publication Date

March 2014

Volume

13

Issue

3

Start / End Page

308 / 316

Related Subject Headings

  • Polymers
  • Nanoscience & Nanotechnology
  • Nanofibers
  • Hydrogels
  • Humans
  • Heterografts
  • Glioblastoma
  • Brain Neoplasms
 

Citation

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Jain, A., Betancur, M., Patel, G. D., Valmikinathan, C. M., Mukhatyar, V. J., Vakharia, A., … Bellamkonda, R. V. (2014). Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres. Nature Materials, 13(3), 308–316. https://doi.org/10.1038/nmat3878
Jain, Anjana, Martha Betancur, Gaurangkumar D. Patel, Chandra M. Valmikinathan, Vivek J. Mukhatyar, Ajit Vakharia, S Balakrishna Pai, Barunashish Brahma, Tobey J. MacDonald, and Ravi V. Bellamkonda. “Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres.Nature Materials 13, no. 3 (March 2014): 308–16. https://doi.org/10.1038/nmat3878.
Jain A, Betancur M, Patel GD, Valmikinathan CM, Mukhatyar VJ, Vakharia A, et al. Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres. Nature materials. 2014 Mar;13(3):308–16.
Jain, Anjana, et al. “Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres.Nature Materials, vol. 13, no. 3, Mar. 2014, pp. 308–16. Epmc, doi:10.1038/nmat3878.
Jain A, Betancur M, Patel GD, Valmikinathan CM, Mukhatyar VJ, Vakharia A, Pai SB, Brahma B, MacDonald TJ, Bellamkonda RV. Guiding intracortical brain tumour cells to an extracortical cytotoxic hydrogel using aligned polymeric nanofibres. Nature materials. 2014 Mar;13(3):308–316.

Published In

Nature materials

DOI

EISSN

1476-4660

ISSN

1476-1122

Publication Date

March 2014

Volume

13

Issue

3

Start / End Page

308 / 316

Related Subject Headings

  • Polymers
  • Nanoscience & Nanotechnology
  • Nanofibers
  • Hydrogels
  • Humans
  • Heterografts
  • Glioblastoma
  • Brain Neoplasms