A perspective on immunomodulation and tissue repair.

Journal Article (Review;Journal Article)

An immune response involves the action of all types of macrophages, classically activated subtype (M1) in the early inflammatory phase and regulatory and wound-healing subtypes (M2) in the resolution phase. The remarkable plasticity of macrophages makes them an interesting target in the context of immunomodulation. Here, we reviewed the current state of understanding regarding the role that different phenotypes of macrophages and monocytes play following injury and during the course of remodeling in different tissue types. Moreover, we explored recent designs of macrophage modulatory biomaterials for tissue engineering and regenerative medicine applications.

Full Text

Duke Authors

Cited Authors

  • Mokarram, N; Bellamkonda, RV

Published Date

  • February 2014

Published In

Volume / Issue

  • 42 / 2

Start / End Page

  • 338 - 351

PubMed ID

  • 24297492

Pubmed Central ID

  • 24297492

Electronic International Standard Serial Number (EISSN)

  • 1573-9686

International Standard Serial Number (ISSN)

  • 0090-6964

Digital Object Identifier (DOI)

  • 10.1007/s10439-013-0941-0


  • eng