Topography, cell response, and nerve regeneration.
Published
Journal Article (Review)
In the body, cells encounter a complex milieu of signals, including topographical cues, in the form of the physical features of their surrounding environment. Imposed topography can affect cells on surfaces by promoting adhesion, spreading, alignment, morphological changes, and changes in gene expression. Neural response to topography is complex, and it depends on the dimensions and shapes of physical features. Looking toward repair of nerve injuries, strategies are being explored to engineer guidance conduits with precise surface topographies. How neurons and other cell types sense and interpret topography remains to be fully elucidated. Studies reviewed here include those of topography on cellular organization and function as well as potential cellular mechanisms of response.
Full Text
Duke Authors
Cited Authors
- Hoffman-Kim, D; Mitchel, JA; Bellamkonda, RV
Published Date
- August 2010
Published In
Volume / Issue
- 12 /
Start / End Page
- 203 - 231
PubMed ID
- 20438370
Pubmed Central ID
- 20438370
Electronic International Standard Serial Number (EISSN)
- 1545-4274
International Standard Serial Number (ISSN)
- 1523-9829
Digital Object Identifier (DOI)
- 10.1146/annurev-bioeng-070909-105351
Language
- eng