Topography, cell response, and nerve regeneration.

Journal Article (Review;Journal Article)

In the body, cells encounter a complex milieu of signals, including topographical cues, in the form of the physical features of their surrounding environment. Imposed topography can affect cells on surfaces by promoting adhesion, spreading, alignment, morphological changes, and changes in gene expression. Neural response to topography is complex, and it depends on the dimensions and shapes of physical features. Looking toward repair of nerve injuries, strategies are being explored to engineer guidance conduits with precise surface topographies. How neurons and other cell types sense and interpret topography remains to be fully elucidated. Studies reviewed here include those of topography on cellular organization and function as well as potential cellular mechanisms of response.

Full Text

Duke Authors

Cited Authors

  • Hoffman-Kim, D; Mitchel, JA; Bellamkonda, RV

Published Date

  • August 2010

Published In

Volume / Issue

  • 12 /

Start / End Page

  • 203 - 231

PubMed ID

  • 20438370

Pubmed Central ID

  • PMC3016849

Electronic International Standard Serial Number (EISSN)

  • 1545-4274

International Standard Serial Number (ISSN)

  • 1523-9829

Digital Object Identifier (DOI)

  • 10.1146/annurev-bioeng-070909-105351


  • eng