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A novel anti-inflammatory surface for neural electrodes

Publication ,  Journal Article
He, W; McConnell, GC; Schneider, TM; Bellamkonda, RV
Published in: Advanced Materials
November 5, 2007

Researchers have demonstrated through in vitro cell culture studies and in vivo rodent studies that immobilized alpha-MSH creates an inherently anti-inflammatory neural electrode surface such that it significantly attenuates glial response for at least 4 weeks post-implantation. For investigating whether the alpha-MSH peptide remains biologically active when covalently immobilized to the Si surface, primarily rat microglial cells were cultured primarily on the peptide modified surface and subjected the culture to lipopolysaccharide (LPS) bacterial endoxtin. Modulation of the level of TNF-alpha and IL-1 is critical as it not only amplifies the inflammation process by stimulating glial cell proliferation and activation but also cause neuronal death. Indirect signal detection was accomplished by using an anti-DIG antibody, which is conjugated to alkaline phosphatase.

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Published In

Advanced Materials

DOI

ISSN

0935-9648

Publication Date

November 5, 2007

Volume

19

Issue

21

Start / End Page

3529 / 3533

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences
 

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He, W., McConnell, G. C., Schneider, T. M., & Bellamkonda, R. V. (2007). A novel anti-inflammatory surface for neural electrodes. Advanced Materials, 19(21), 3529–3533. https://doi.org/10.1002/adma.200700943
He, W., G. C. McConnell, T. M. Schneider, and R. V. Bellamkonda. “A novel anti-inflammatory surface for neural electrodes.” Advanced Materials 19, no. 21 (November 5, 2007): 3529–33. https://doi.org/10.1002/adma.200700943.
He W, McConnell GC, Schneider TM, Bellamkonda RV. A novel anti-inflammatory surface for neural electrodes. Advanced Materials. 2007 Nov 5;19(21):3529–33.
He, W., et al. “A novel anti-inflammatory surface for neural electrodes.” Advanced Materials, vol. 19, no. 21, Nov. 2007, pp. 3529–33. Scopus, doi:10.1002/adma.200700943.
He W, McConnell GC, Schneider TM, Bellamkonda RV. A novel anti-inflammatory surface for neural electrodes. Advanced Materials. 2007 Nov 5;19(21):3529–3533.
Journal cover image

Published In

Advanced Materials

DOI

ISSN

0935-9648

Publication Date

November 5, 2007

Volume

19

Issue

21

Start / End Page

3529 / 3533

Related Subject Headings

  • Nanoscience & Nanotechnology
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences