Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.

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Journal Article

Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.

Full Text

Duke Authors

Cited Authors

  • Fan, Q; Verhoeven, VJM; Wojciechowski, R; Barathi, VA; Hysi, PG; Guggenheim, JA; Höhn, R; Vitart, V; Khawaja, AP; Yamashiro, K; Hosseini, SM; Lehtimäki, T; Lu, Y; Haller, T; Xie, J; Delcourt, C; Pirastu, M; Wedenoja, J; Gharahkhani, P; Venturini, C; Miyake, M; Hewitt, AW; Guo, X; Mazur, J; Huffman, JE; Williams, KM; Polasek, O; Campbell, H; Rudan, I; Vatavuk, Z; Wilson, JF; Joshi, PK; McMahon, G; St Pourcain, B; Evans, DM; Simpson, CL; Schwantes-An, T-H; Igo, RP; Mirshahi, A; Cougnard-Gregoire, A; Bellenguez, C; Blettner, M; Raitakari, O; Kähönen, M; Seppala, I; Zeller, T; Meitinger, T; Consortium for Refractive Error and Myopia, ; Ried, JS; Gieger, C; Portas, L; van Leeuwen, EM; Amin, N; Uitterlinden, AG; Rivadeneira, F; Hofman, A; Vingerling, JR; Wang, YX; Wang, X; Tai-Hui Boh, E; Ikram, MK; Sabanayagam, C; Gupta, P; Tan, V; Zhou, L; Ho, CEH; Lim, W; Beuerman, RW; Siantar, R; Tai, E-S; Vithana, E; Mihailov, E; Khor, C-C; Hayward, C; Luben, RN; Foster, PJ; Klein, BEK; Klein, R; Wong, H-S; Mitchell, P; Metspalu, A; Aung, T; Young, TL; He, M; Pärssinen, O; van Duijn, CM; Jin Wang, J; Williams, C; Jonas, JB; Teo, Y-Y; Mackey, DA; Oexle, K; Yoshimura, N; Paterson, AD; Pfeiffer, N; Wong, T-Y; Baird, PN; Stambolian, D; Wilson, JEB; Cheng, C-Y; Hammond, CJ; Klaver, CCW; Saw, S-M; Rahi, JS; Korobelnik, J-F; Kemp, JP; Timpson, NJ; Smith, GD; Craig, JE; Burdon, KP; Fogarty, RD; Iyengar, SK; Chew, E; Janmahasatian, S; Martin, NG; MacGregor, S; Xu, L; Schache, M; Nangia, V; Panda-Jonas, S; Wright, AF; Fondran, JR; Lass, JH; Feng, S; Zhao, JH; Khaw, K-T; Wareham, NJ; Rantanen, T; Kaprio, J; Pang, CP; Chen, LJ; Tam, PO; Jhanji, V; Young, AL; Döring, A; Raffel, LJ; Cotch, M-F; Li, X; Yip, SP; Yap, MKH; Biino, G; Vaccargiu, S; Fossarello, M; Fleck, B; Yazar, S; Tideman, JWL; Tedja, M; Deangelis, MM; Morrison, M; Farrer, L; Zhou, X; Chen, W; Mizuki, N; Meguro, A; Mäkelä, KM

Published Date

  • March 29, 2016

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 11008 -

PubMed ID

  • 27020472

Pubmed Central ID

  • 27020472

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms11008

Language

  • eng

Conference Location

  • England