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Analysis of Factors Associated With In-hospital Mortality in Lung Cancer Chemotherapy Patients With Neutropenia.

Publication ,  Conference
Cupp, J; Culakova, E; Poniewierski, MS; Dale, DC; Lyman, GH; Crawford, J
Published in: Clin Lung Cancer
March 2018

Lung cancer, compared with other solid tumors, is associated with high mortality rates from febrile neutropenia. The risk factors associated with in-hospital mortality were identified and compared for patients with lung cancer and patients with other solid tumors. Hospitalization data from the University Health Consortium database inclusive of 2004 to 2012 were analyzed. The study population included all adult patients with solid tumors who developed neutropenia. Cancer type, the presence of neutropenia, and further subgroups were determined using International Classification of Diseases, 9th revision, Clinical Modification codes. The primary study outcome was in-hospital mortality in lung cancer patients versus those with other solid tumors. Further analysis concentrated on comparisons of the 2 groups. The analysis included data from 11,111 lung cancer patients and 49,975 patients with other solid tumors. Overall, 4290 patients (7.0%) died. Lung cancer was associated with highest mortality (11.2% compared with other solid tumors, 6.1%; P < .0001). The lung cancer patients were older and more likely to have multiple comorbidities, and the risk of mortality was directly related to the number of comorbidities. Four additional risk factors for mortality were identified: pneumonia, sepsis, any infection, and intensive care unit stay. Pneumonia occurred more commonly in the lung cancer patients (26.4% vs. 10.3%) and was associated with comorbid pulmonary disease, which also occurred more often in the lung cancer patients (52.1% vs. 24.0%). We found that lung cancer patients presenting with febrile neutropenia were older, had more comorbidities, had a greater incidence of comorbid pulmonary disease, and were more likely to have pneumonia. Awareness of these risk factors for mortality should guide clinicians for more personalized approaches to chemotherapy, supportive care decisions, pneumonia and comorbidities.

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Published In

Clin Lung Cancer

DOI

EISSN

1938-0690

Publication Date

March 2018

Volume

19

Issue

2

Start / End Page

e163 / e169

Location

United States

Related Subject Headings

  • United States
  • Sepsis
  • Risk Factors
  • Precision Medicine
  • Pneumonia
  • Oncology & Carcinogenesis
  • Neutropenia
  • Lung Neoplasms
  • Humans
  • Hospital Mortality
 

Citation

APA
Chicago
ICMJE
MLA
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Cupp, J., Culakova, E., Poniewierski, M. S., Dale, D. C., Lyman, G. H., & Crawford, J. (2018). Analysis of Factors Associated With In-hospital Mortality in Lung Cancer Chemotherapy Patients With Neutropenia. In Clin Lung Cancer (Vol. 19, pp. e163–e169). United States. https://doi.org/10.1016/j.cllc.2017.10.013
Cupp, Julia, Eva Culakova, Marek S. Poniewierski, David C. Dale, Gary H. Lyman, and Jeffrey Crawford. “Analysis of Factors Associated With In-hospital Mortality in Lung Cancer Chemotherapy Patients With Neutropenia.” In Clin Lung Cancer, 19:e163–69, 2018. https://doi.org/10.1016/j.cllc.2017.10.013.
Cupp J, Culakova E, Poniewierski MS, Dale DC, Lyman GH, Crawford J. Analysis of Factors Associated With In-hospital Mortality in Lung Cancer Chemotherapy Patients With Neutropenia. In: Clin Lung Cancer. 2018. p. e163–9.
Cupp, Julia, et al. “Analysis of Factors Associated With In-hospital Mortality in Lung Cancer Chemotherapy Patients With Neutropenia.Clin Lung Cancer, vol. 19, no. 2, 2018, pp. e163–69. Pubmed, doi:10.1016/j.cllc.2017.10.013.
Cupp J, Culakova E, Poniewierski MS, Dale DC, Lyman GH, Crawford J. Analysis of Factors Associated With In-hospital Mortality in Lung Cancer Chemotherapy Patients With Neutropenia. Clin Lung Cancer. 2018. p. e163–e169.
Journal cover image

Published In

Clin Lung Cancer

DOI

EISSN

1938-0690

Publication Date

March 2018

Volume

19

Issue

2

Start / End Page

e163 / e169

Location

United States

Related Subject Headings

  • United States
  • Sepsis
  • Risk Factors
  • Precision Medicine
  • Pneumonia
  • Oncology & Carcinogenesis
  • Neutropenia
  • Lung Neoplasms
  • Humans
  • Hospital Mortality