Ventricular arrhythmia burst is an independent indicator of larger infarct size even in optimal reperfusion in STEMI.

Published

Journal Article

OBJECTIVE: We hypothesized that ventricular arrhythmia (VA) bursts during reperfusion phase are a marker of larger infarct size despite optimal epicardial and microvascular perfusion. METHODS: 126 STEMI patients were studied with 24h continuous, 12-lead Holter monitoring. Myocardial blush grade (MBG) was determined and VA bursts were identified against subject-specific background VA rates in core laboratories. Delayed-enhancement cardiovascular magnetic resonance imaging was used to determine infarct size. RESULTS: In the group with MBG 3 no significant differences were found for baseline characteristics between burst versus no burst (102 vs. 24). In those with optimal epicardial and microvascular reperfusion (TIMI 3, stable ST-recovery, and MBG 3), VA burst was associated with larger infarct size (N=102/126; median 11.0 vs. 5.1%; p=0.004). CONCLUSION: In the event of MBG 3, VA bursts were associated with significantly larger infarct size even if optimal epicardial and microvascular reperfusion was present.

Full Text

Duke Authors

Cited Authors

  • van der Weg, K; Majidi, M; Haeck, JDE; Tijssen, JGP; Green, CL; Koch, KT; Kuijt, WJ; Krucoff, MW; Gorgels, APM; de Winter, RJ

Published Date

  • May 2016

Published In

Volume / Issue

  • 49 / 3

Start / End Page

  • 345 - 352

PubMed ID

  • 27034119

Pubmed Central ID

  • 27034119

Electronic International Standard Serial Number (EISSN)

  • 1532-8430

Digital Object Identifier (DOI)

  • 10.1016/j.jelectrocard.2016.03.013

Language

  • eng

Conference Location

  • United States