Skip to main content

Interobserver Reproducibility of the PI-RADS Version 2 Lexicon: A Multicenter Study of Six Experienced Prostate Radiologists.

Publication ,  Journal Article
Rosenkrantz, AB; Ginocchio, LA; Cornfeld, D; Froemming, AT; Gupta, RT; Turkbey, B; Westphalen, AC; Babb, JS; Margolis, DJ
Published in: Radiology
September 2016

Purpose To determine the interobserver reproducibility of the Prostate Imaging Reporting and Data System (PI-RADS) version 2 lexicon. Materials and Methods This retrospective HIPAA-compliant study was institutional review board-approved. Six radiologists from six separate institutions, all experienced in prostate magnetic resonance (MR) imaging, assessed prostate MR imaging examinations performed at a single center by using the PI-RADS lexicon. Readers were provided screen captures that denoted the location of one specific lesion per case. Analysis entailed two sessions (40 and 80 examinations per session) and an intersession training period for individualized feedback and group discussion. Percent agreement (fraction of pairwise reader combinations with concordant readings) was compared between sessions. κ coefficients were computed. Results No substantial difference in interobserver agreement was observed between sessions, and the sessions were subsequently pooled. Agreement for PI-RADS score of 4 or greater was 0.593 in peripheral zone (PZ) and 0.509 in transition zone (TZ). In PZ, reproducibility was moderate to substantial for features related to diffusion-weighted imaging (κ = 0.535-0.619); fair to moderate for features related to dynamic contrast material-enhanced (DCE) imaging (κ = 0.266-0.439); and fair for definite extraprostatic extension on T2-weighted images (κ = 0.289). In TZ, reproducibility for features related to lesion texture and margins on T2-weighted images ranged from 0.136 (moderately hypointense) to 0.529 (encapsulation). Among 63 lesions that underwent targeted biopsy, classification as PI-RADS score of 4 or greater by a majority of readers yielded tumor with a Gleason score of 3+4 or greater in 45.9% (17 of 37), without missing any tumor with a Gleason score of 3+4 or greater. Conclusion Experienced radiologists achieved moderate reproducibility for PI-RADS version 2, and neither required nor benefitted from a training session. Agreement tended to be better in PZ than TZ, although was weak for DCE in PZ. The findings may help guide future PI-RADS lexicon updates. (©) RSNA, 2016 Online supplemental material is available for this article.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

September 2016

Volume

280

Issue

3

Start / End Page

793 / 804

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Prostatic Diseases
  • Practice Patterns, Physicians'
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Grading
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rosenkrantz, A. B., Ginocchio, L. A., Cornfeld, D., Froemming, A. T., Gupta, R. T., Turkbey, B., … Margolis, D. J. (2016). Interobserver Reproducibility of the PI-RADS Version 2 Lexicon: A Multicenter Study of Six Experienced Prostate Radiologists. Radiology, 280(3), 793–804. https://doi.org/10.1148/radiol.2016152542
Rosenkrantz, Andrew B., Luke A. Ginocchio, Daniel Cornfeld, Adam T. Froemming, Rajan T. Gupta, Baris Turkbey, Antonio C. Westphalen, James S. Babb, and Daniel J. Margolis. “Interobserver Reproducibility of the PI-RADS Version 2 Lexicon: A Multicenter Study of Six Experienced Prostate Radiologists.Radiology 280, no. 3 (September 2016): 793–804. https://doi.org/10.1148/radiol.2016152542.
Rosenkrantz AB, Ginocchio LA, Cornfeld D, Froemming AT, Gupta RT, Turkbey B, et al. Interobserver Reproducibility of the PI-RADS Version 2 Lexicon: A Multicenter Study of Six Experienced Prostate Radiologists. Radiology. 2016 Sep;280(3):793–804.
Rosenkrantz, Andrew B., et al. “Interobserver Reproducibility of the PI-RADS Version 2 Lexicon: A Multicenter Study of Six Experienced Prostate Radiologists.Radiology, vol. 280, no. 3, Sept. 2016, pp. 793–804. Pubmed, doi:10.1148/radiol.2016152542.
Rosenkrantz AB, Ginocchio LA, Cornfeld D, Froemming AT, Gupta RT, Turkbey B, Westphalen AC, Babb JS, Margolis DJ. Interobserver Reproducibility of the PI-RADS Version 2 Lexicon: A Multicenter Study of Six Experienced Prostate Radiologists. Radiology. 2016 Sep;280(3):793–804.

Published In

Radiology

DOI

EISSN

1527-1315

Publication Date

September 2016

Volume

280

Issue

3

Start / End Page

793 / 804

Location

United States

Related Subject Headings

  • Retrospective Studies
  • Reproducibility of Results
  • Prostatic Diseases
  • Practice Patterns, Physicians'
  • Organometallic Compounds
  • Nuclear Medicine & Medical Imaging
  • Neoplasm Grading
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging