Protection against SHIV Challenge by Subcutaneous Administration of the Plant-Derived PGT121 Broadly Neutralizing Antibody in Macaques.

Published online

Journal Article

Intravascular delivery of broadly neutralizing antibodies (bnAbs) has shown promise for prevention and treatment of HIV infection. However, multiple IV administrations in geographic locations with poor accessibility to medical care have practical limitations. We have assessed the efficacy of plant-derived PGT121 delivered subcutaneously (SC) against pre-and post-intravaginal challenge using a rigorous SHIV-SF162P3 macaque protection model. SC administered PGT121 exhibited a longer serum half-life than IV administration and was more consistent than intramuscular delivery. A dose of 3.5mg/kg PGT121 prevented infection at a minimum ID50 neutralization titer of 1:295 while 5mg/kg protected five of six macaques when delivered immediately post-challenge. These results suggest the utility of plant-derived bnAbs delivered SC for HIV prevention.

Full Text

Duke Authors

Cited Authors

  • Rosenberg, YJ; Montefiori, DC; LaBranche, CC; Lewis, MG; Sack, M; Lees, JP; Jiang, X

Published Date

  • 2016

Published In

Volume / Issue

  • 11 / 3

Start / End Page

  • e0152760 -

PubMed ID

  • 27031108

Pubmed Central ID

  • 27031108

Electronic International Standard Serial Number (EISSN)

  • 1932-6203

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0152760

Language

  • eng

Conference Location

  • United States