Ankyrin-B in lens architecture and biomechanics: Just not tethering but more.

Published

Journal Article

The ankyrins are a family of well-characterized metazoan adaptor proteins that play a key role in linking various membrane-spanning proteins to the underlying spectrin-actin cytoskeleton; a mechanistic understanding of their role in tissue architecture and mechanics, however, remains elusive. Here we comment on a recent study demonstrating a key role for ankyrin-B in maintaining the hexagonal shape and radial alignment of ocular lens fiber cells by regulating the membrane organization of periaxin, dystrophins/dystroglycan, NrCAM and spectrin-actin network of proteins, and revealing that ankyrin-B deficiency impairs fiber cell shape and mechanical properties of the ocular lens. These observations indicate that ankyrin-B plays an important role in maintaining tissue cytoarchitecture, cell shape and biomechanical properties via engaging in key protein: protein interactions required for membrane anchoring and organization of the spectrin-actin skeleton, scaffolding proteins and cell adhesive proteins.

Full Text

Duke Authors

Cited Authors

  • Rao, PV; Maddala, R

Published Date

  • January 2016

Published In

Volume / Issue

  • 6 / 2

Start / End Page

  • 39 - 45

PubMed ID

  • 27044909

Pubmed Central ID

  • 27044909

Electronic International Standard Serial Number (EISSN)

  • 1949-100X

International Standard Serial Number (ISSN)

  • 1949-0992

Digital Object Identifier (DOI)

  • 10.1080/19490992.2016.1156284

Language

  • eng