Skip to main content

A GABAergic nigrotectal pathway for coordination of drinking behavior.

Publication ,  Journal Article
Rossi, MA; Li, HE; Lu, D; Kim, IH; Bartholomew, RA; Gaidis, E; Barter, JW; Kim, N; Cai, MT; Soderling, SH; Yin, HH
Published in: Nat Neurosci
May 2016

The contribution of basal ganglia outputs to consummatory behavior remains poorly understood. We recorded from the substantia nigra pars reticulata (SNR), the major basal ganglia output nucleus, during self-initiated drinking in mice. The firing rates of many lateral SNR neurons were time-locked to individual licks. These neurons send GABAergic projections to the deep layers of the orofacial region of the lateral tectum (superior colliculus, SC). Many tectal neurons were also time-locked to licking, but their activity was usually in antiphase with that of SNR neurons, suggesting inhibitory nigrotectal projections. We used optogenetics to selectively activate the GABAergic nigrotectal afferents in the deep layers of the SC. Photo-stimulation of the nigrotectal projections transiently inhibited the activity of the lick-related tectal neurons, disrupted their licking-related oscillatory pattern and suppressed self-initiated drinking. These results demonstrate that GABAergic nigrotectal projections have a crucial role in coordinating drinking behavior.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

May 2016

Volume

19

Issue

5

Start / End Page

742 / 748

Location

United States

Related Subject Headings

  • Superior Colliculi
  • Pars Reticulata
  • Neurology & Neurosurgery
  • Neural Pathways
  • Neural Inhibition
  • Muscimol
  • Microinjections
  • Mice, Transgenic
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Rossi, M. A., Li, H. E., Lu, D., Kim, I. H., Bartholomew, R. A., Gaidis, E., … Yin, H. H. (2016). A GABAergic nigrotectal pathway for coordination of drinking behavior. Nat Neurosci, 19(5), 742–748. https://doi.org/10.1038/nn.4285
Rossi, Mark A., Haofang E. Li, Dongye Lu, Il Hwan Kim, Ryan A. Bartholomew, Erin Gaidis, Joseph W. Barter, et al. “A GABAergic nigrotectal pathway for coordination of drinking behavior.Nat Neurosci 19, no. 5 (May 2016): 742–48. https://doi.org/10.1038/nn.4285.
Rossi MA, Li HE, Lu D, Kim IH, Bartholomew RA, Gaidis E, et al. A GABAergic nigrotectal pathway for coordination of drinking behavior. Nat Neurosci. 2016 May;19(5):742–8.
Rossi, Mark A., et al. “A GABAergic nigrotectal pathway for coordination of drinking behavior.Nat Neurosci, vol. 19, no. 5, May 2016, pp. 742–48. Pubmed, doi:10.1038/nn.4285.
Rossi MA, Li HE, Lu D, Kim IH, Bartholomew RA, Gaidis E, Barter JW, Kim N, Cai MT, Soderling SH, Yin HH. A GABAergic nigrotectal pathway for coordination of drinking behavior. Nat Neurosci. 2016 May;19(5):742–748.

Published In

Nat Neurosci

DOI

EISSN

1546-1726

Publication Date

May 2016

Volume

19

Issue

5

Start / End Page

742 / 748

Location

United States

Related Subject Headings

  • Superior Colliculi
  • Pars Reticulata
  • Neurology & Neurosurgery
  • Neural Pathways
  • Neural Inhibition
  • Muscimol
  • Microinjections
  • Mice, Transgenic
  • Mice
  • Male