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Pharmacology, physiology, and mechanisms of incretin hormone action.

Publication ,  Journal Article
Campbell, JE; Drucker, DJ
Published in: Cell Metab
June 4, 2013

Incretin peptides, principally GLP-1 and GIP, regulate islet hormone secretion, glucose concentrations, lipid metabolism, gut motility, appetite and body weight, and immune function, providing a scientific basis for utilizing incretin-based therapies in the treatment of type 2 diabetes. Activation of GLP-1 and GIP receptors also leads to nonglycemic effects in multiple tissues, through direct actions on tissues expressing incretin receptors and indirect mechanisms mediated through neuronal and endocrine pathways. Here we contrast the pharmacology and physiology of incretin hormones and review recent advances in mechanisms coupling incretin receptor signaling to pleiotropic metabolic actions in preclinical studies. We discuss whether mechanisms identified in preclinical studies have potential translational relevance for the treatment of human disease and highlight controversies and uncertainties in incretin biology that require resolution in future studies.

Duke Scholars

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Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

June 4, 2013

Volume

17

Issue

6

Start / End Page

819 / 837

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Gastrointestinal Hormone
  • Mice
  • Islets of Langerhans
  • Incretins
  • Humans
  • Glucagon-Like Peptide 1
  • Gastric Inhibitory Polypeptide
  • Endocrinology & Metabolism
  • Animals
 

Citation

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Campbell, J. E., & Drucker, D. J. (2013). Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab, 17(6), 819–837. https://doi.org/10.1016/j.cmet.2013.04.008
Campbell, Jonathan E., and Daniel J. Drucker. “Pharmacology, physiology, and mechanisms of incretin hormone action.Cell Metab 17, no. 6 (June 4, 2013): 819–37. https://doi.org/10.1016/j.cmet.2013.04.008.
Campbell JE, Drucker DJ. Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab. 2013 Jun 4;17(6):819–37.
Campbell, Jonathan E., and Daniel J. Drucker. “Pharmacology, physiology, and mechanisms of incretin hormone action.Cell Metab, vol. 17, no. 6, June 2013, pp. 819–37. Pubmed, doi:10.1016/j.cmet.2013.04.008.
Campbell JE, Drucker DJ. Pharmacology, physiology, and mechanisms of incretin hormone action. Cell Metab. 2013 Jun 4;17(6):819–837.
Journal cover image

Published In

Cell Metab

DOI

EISSN

1932-7420

Publication Date

June 4, 2013

Volume

17

Issue

6

Start / End Page

819 / 837

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Gastrointestinal Hormone
  • Mice
  • Islets of Langerhans
  • Incretins
  • Humans
  • Glucagon-Like Peptide 1
  • Gastric Inhibitory Polypeptide
  • Endocrinology & Metabolism
  • Animals