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Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training.

Publication ,  Journal Article
Campbell, JE; Rakhshani, N; Fediuc, S; Bruni, S; Riddell, MC
Published in: J Appl Physiol (1985)
January 2009

Although exercise is a common and potent activator of the hypothalamic-pituitary adrenal (HPA) axis, the effects of exercise on the acute stress response are not well understood. Here, we investigated the effects of short- (2 wk) and long-term (8 wk) voluntary wheel running on adrenal sensitivity to ACTH stimulation and the acute stress response to restraint in male rats. Diurnal glucocorticoid patterns were measured on days 7 (all groups) and 35 (8-wk groups). Rats were subjected to 20 min of restraint stress on either week 1 or on week 7 of treatment to assess HPA activation. One week later, exogenous ACTH (75 ng/kg) was administered to assess adrenal sensitivity to ACTH. Following this, adrenals were collected and analyzed for key proteins involved in corticosterone (CORT) synthesis. By the end of week 1, exercising (E) animals had twofold higher peak diurnal CORT levels compared with sedentary (S) animals (P < 0.01). CORT values were not different between groups at week 8. In response to restraint stress at week 2, CORT values in E were approximately threefold greater than in S (P < 0.05). No difference was found between E and S rats in the response to, or recovery from, restraint at week 8. During the ACTH challenge at week 2, E demonstrated a approximately 2.5-fold increase in adrenal sensitivity compared with S, while no difference was found between E and S at week 8. The expression of steroidogenic acute regulatory protein was found to be approximately 50% higher in the adrenals in E compared with S at week 2 (P < 0.05), but no difference existed between groups at week 8. These results show that volitional wheel running initially causes hyperactivation of the HPA axis, due to enhanced adrenal sensitivity to ACTH, but that these alterations in HPA activity are completely restored by 8 wk of training.

Duke Scholars

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

January 2009

Volume

106

Issue

1

Start / End Page

66 / 72

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Running
  • Restraint, Physical
  • Receptor, Melanocortin, Type 2
  • Rats, Sprague-Dawley
  • Rats
  • Pituitary-Adrenal System
  • Pituitary-Adrenal Function Tests
  • Physiology
  • Physical Exertion
 

Citation

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Campbell, J. E., Rakhshani, N., Fediuc, S., Bruni, S., & Riddell, M. C. (2009). Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training. J Appl Physiol (1985), 106(1), 66–72. https://doi.org/10.1152/japplphysiol.91128.2008
Campbell, Jonathan E., Nasimeh Rakhshani, Sergiu Fediuc, Silvio Bruni, and Michael C. Riddell. “Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training.J Appl Physiol (1985) 106, no. 1 (January 2009): 66–72. https://doi.org/10.1152/japplphysiol.91128.2008.
Campbell JE, Rakhshani N, Fediuc S, Bruni S, Riddell MC. Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training. J Appl Physiol (1985). 2009 Jan;106(1):66–72.
Campbell, Jonathan E., et al. “Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training.J Appl Physiol (1985), vol. 106, no. 1, Jan. 2009, pp. 66–72. Pubmed, doi:10.1152/japplphysiol.91128.2008.
Campbell JE, Rakhshani N, Fediuc S, Bruni S, Riddell MC. Voluntary wheel running initially increases adrenal sensitivity to adrenocorticotrophic hormone, which is attenuated with long-term training. J Appl Physiol (1985). 2009 Jan;106(1):66–72.

Published In

J Appl Physiol (1985)

DOI

ISSN

8750-7587

Publication Date

January 2009

Volume

106

Issue

1

Start / End Page

66 / 72

Location

United States

Related Subject Headings

  • Stress, Psychological
  • Running
  • Restraint, Physical
  • Receptor, Melanocortin, Type 2
  • Rats, Sprague-Dawley
  • Rats
  • Pituitary-Adrenal System
  • Pituitary-Adrenal Function Tests
  • Physiology
  • Physical Exertion