Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography.

Journal Article (Journal Article)

Angle-resolved low coherence interferometry (a/LCI) is an optical technique used to measure nuclear morphology in situ. However, a/LCI is not an imaging modality and can produce ambiguous results when the measurements are not properly oriented to the tissue architecture. Here we present a 2D a/LCI system which incorporates optical coherence tomography imaging to guide the measurements. System design and characterization are presented, along with example cases which demonstrate the utility of the combined measurements. In addition, future development and applications of this dual modality approach are discussed.

Full Text

Duke Authors

Cited Authors

  • Kim, S; Heflin, S; Kresty, LA; Halling, M; Perez, LN; Ho, D; Crose, M; Brown, W; Farsiu, S; Arshavsky, V; Wax, A

Published Date

  • April 1, 2016

Published In

Volume / Issue

  • 7 / 4

Start / End Page

  • 1400 - 1414

PubMed ID

  • 27446664

Pubmed Central ID

  • 27446664

International Standard Serial Number (ISSN)

  • 2156-7085

Digital Object Identifier (DOI)

  • 10.1364/BOE.7.001400


  • eng

Conference Location

  • United States