Skip to main content

Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer.

Publication ,  Journal Article
van der Heijden, AG; Dewhirst, MW
Published in: Int J Hyperthermia
June 2016

Non-muscle-invasive bladder cancer is a challenging disease, even given its superficial nature. It is prone to multiple recurrences and progression to muscle-invasive cancer. These features of this disease contribute significantly to reduced quality of life as well as creating significant morbidity and even mortality. Randomised trials demonstrate that when hyperthermia is added to conventional mitomycin-C treatment that local control rates and progression-free survival are substantially improved. In this review we consider how hyperthermia can exert such beneficial effects. Some of the mechanisms presented are theoretical, while others are facts. It is hoped that this review will contribute rationale for further examination of mechanisms, because an understanding of such mechanisms may lead to even better chemotherapeutic approaches, as well as potential biomarkers for predicting and monitoring treatment success.

Duke Scholars

Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

June 2016

Volume

32

Issue

4

Start / End Page

434 / 445

Location

England

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Oncology & Carcinogenesis
  • Hyperthermia, Induced
  • Humans
  • Drug Resistance, Neoplasm
  • Combined Modality Therapy
  • Biological Transport
  • Antineoplastic Agents
  • Animals
  • 3202 Clinical sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
van der Heijden, A. G., & Dewhirst, M. W. (2016). Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer. Int J Hyperthermia, 32(4), 434–445. https://doi.org/10.3109/02656736.2016.1155761
Heijden, Antoine G. van der, and Mark W. Dewhirst. “Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer.Int J Hyperthermia 32, no. 4 (June 2016): 434–45. https://doi.org/10.3109/02656736.2016.1155761.
van der Heijden AG, Dewhirst MW. Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer. Int J Hyperthermia. 2016 Jun;32(4):434–45.
van der Heijden, Antoine G., and Mark W. Dewhirst. “Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer.Int J Hyperthermia, vol. 32, no. 4, June 2016, pp. 434–45. Pubmed, doi:10.3109/02656736.2016.1155761.
van der Heijden AG, Dewhirst MW. Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer. Int J Hyperthermia. 2016 Jun;32(4):434–445.

Published In

Int J Hyperthermia

DOI

EISSN

1464-5157

Publication Date

June 2016

Volume

32

Issue

4

Start / End Page

434 / 445

Location

England

Related Subject Headings

  • Urinary Bladder Neoplasms
  • Oncology & Carcinogenesis
  • Hyperthermia, Induced
  • Humans
  • Drug Resistance, Neoplasm
  • Combined Modality Therapy
  • Biological Transport
  • Antineoplastic Agents
  • Animals
  • 3202 Clinical sciences