Effects of hyperthermia in neutralising mechanisms of drug resistance in non-muscle-invasive bladder cancer.


Journal Article (Review)

Non-muscle-invasive bladder cancer is a challenging disease, even given its superficial nature. It is prone to multiple recurrences and progression to muscle-invasive cancer. These features of this disease contribute significantly to reduced quality of life as well as creating significant morbidity and even mortality. Randomised trials demonstrate that when hyperthermia is added to conventional mitomycin-C treatment that local control rates and progression-free survival are substantially improved. In this review we consider how hyperthermia can exert such beneficial effects. Some of the mechanisms presented are theoretical, while others are facts. It is hoped that this review will contribute rationale for further examination of mechanisms, because an understanding of such mechanisms may lead to even better chemotherapeutic approaches, as well as potential biomarkers for predicting and monitoring treatment success.

Full Text

Duke Authors

Cited Authors

  • van der Heijden, AG; Dewhirst, MW

Published Date

  • June 2016

Published In

Volume / Issue

  • 32 / 4

Start / End Page

  • 434 - 445

PubMed ID

  • 27098923

Pubmed Central ID

  • 27098923

Electronic International Standard Serial Number (EISSN)

  • 1464-5157

Digital Object Identifier (DOI)

  • 10.3109/02656736.2016.1155761


  • eng

Conference Location

  • England