Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex.

Published

Journal Article

Bioresorbable silicon electronics technology offers unprecedented opportunities to deploy advanced implantable monitoring systems that eliminate risks, cost and discomfort associated with surgical extraction. Applications include postoperative monitoring and transient physiologic recording after percutaneous or minimally invasive placement of vascular, cardiac, orthopaedic, neural or other devices. We present an embodiment of these materials in both passive and actively addressed arrays of bioresorbable silicon electrodes with multiplexing capabilities, which record in vivo electrophysiological signals from the cortical surface and the subgaleal space. The devices detect normal physiologic and epileptiform activity, both in acute and chronic recordings. Comparative studies show sensor performance comparable to standard clinical systems and reduced tissue reactivity relative to conventional clinical electrocorticography (ECoG) electrodes. This technology offers general applicability in neural interfaces, with additional potential utility in treatment of disorders where transient monitoring and modulation of physiologic function, implant integrity and tissue recovery or regeneration are required.

Full Text

Duke Authors

Cited Authors

  • Yu, KJ; Kuzum, D; Hwang, S-W; Kim, BH; Juul, H; Kim, NH; Won, SM; Chiang, K; Trumpis, M; Richardson, AG; Cheng, H; Fang, H; Thomson, M; Bink, H; Talos, D; Seo, KJ; Lee, HN; Kang, S-K; Kim, J-H; Lee, JY; Huang, Y; Jensen, FE; Dichter, MA; Lucas, TH; Viventi, J; Litt, B; Rogers, JA

Published Date

  • July 2016

Published In

Volume / Issue

  • 15 / 7

Start / End Page

  • 782 - 791

PubMed ID

  • 27088236

Pubmed Central ID

  • 27088236

International Standard Serial Number (ISSN)

  • 1476-1122

Digital Object Identifier (DOI)

  • 10.1038/nmat4624

Language

  • eng