Low excitatory innervation balances high intrinsic excitability of immature dentate neurons.

Published online

Journal Article

Persistent neurogenesis in the dentate gyrus produces immature neurons with high intrinsic excitability and low levels of inhibition that are predicted to be more broadly responsive to afferent activity than mature neurons. Mounting evidence suggests that these immature neurons are necessary for generating distinct neural representations of similar contexts, but it is unclear how broadly responsive neurons help distinguish between similar patterns of afferent activity. Here we show that stimulation of the entorhinal cortex in mouse brain slices paradoxically generates spiking of mature neurons in the absence of immature neuron spiking. Immature neurons with high intrinsic excitability fail to spike due to insufficient excitatory drive that results from low innervation rather than silent synapses or low release probability. Our results suggest that low synaptic connectivity prevents immature neurons from responding broadly to cortical activity, potentially enabling excitable immature neurons to contribute to sparse and orthogonal dentate representations.

Full Text

Duke Authors

Cited Authors

  • Dieni, CV; Panichi, R; Aimone, JB; Kuo, CT; Wadiche, JI; Overstreet-Wadiche, L

Published Date

  • April 20, 2016

Published In

Volume / Issue

  • 7 /

Start / End Page

  • 11313 -

PubMed ID

  • 27095423

Pubmed Central ID

  • 27095423

Electronic International Standard Serial Number (EISSN)

  • 2041-1723

Digital Object Identifier (DOI)

  • 10.1038/ncomms11313

Language

  • eng

Conference Location

  • England