The exon junction complex in neural development and neurodevelopmental disease.

Published

Journal Article (Review)

Post-transcriptional mRNA metabolism has emerged as a critical regulatory nexus in proper development and function of the nervous system. In particular, recent studies highlight roles for the exon junction complex (EJC) in neurodevelopment. The EJC is an RNA binding complex composed of 3 core proteins, EIF4A3 (DDX48), RBM8A (Y14), and MAGOH, and is a major hub of post-transcriptional regulation. Following deposition onto mRNA, the EJC serves as a platform for the binding of peripheral factors which together regulate splicing, nonsense mediated decay, translation, and RNA localization. While fundamental molecular roles of the EJC have been well established, the in vivo relevance in mammals has only recently been examined. New genetic models and cellular assays have revealed core and peripheral EJC components play critical roles in brain development, stem cell function, neuronal outgrowth, and neuronal activity. Moreover, human genetics studies increasingly implicate EJC components in the etiology of neurodevelopmental disorders. Collectively, these findings indicate that proper dosage of EJC components is necessary for diverse aspects of neuronal development and function. Going forward, genetic models of EJC components will provide valuable tools for further elucidating functions in the nervous system relevant for neurodevelopmental disease.

Full Text

Duke Authors

Cited Authors

  • McMahon, JJ; Miller, EE; Silver, DL

Published Date

  • December 2016

Published In

Volume / Issue

  • 55 /

Start / End Page

  • 117 - 123

PubMed ID

  • 27071691

Pubmed Central ID

  • 27071691

Electronic International Standard Serial Number (EISSN)

  • 1873-474X

International Standard Serial Number (ISSN)

  • 0736-5748

Digital Object Identifier (DOI)

  • 10.1016/j.ijdevneu.2016.03.006

Language

  • eng