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Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem.

Publication ,  Journal Article
Thiele, TE; Seeley, RJ; D'Alessio, D; Eng, J; Bernstein, IL; Woods, SC; van Dijk, G
Published in: Brain Res
August 10, 1998

Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) and intraperitoneal (i.p.) injection of lithium chloride (LiCl) produce similar patterns of c-Fos induction in the rat brain. These similarities led us to assess the hypothesis that neuronal activity caused by i.p. injection of LiCl involves activation of central GLP-1 pathways. We therefore determined if third-ventricular (i3vt) infusion of a GLP-1 receptor antagonist would block LiCl-induced c-Fos expression in the brainstem. Relative to rats pretreated with i3vt infusion of vehicle, pretreatment with the potent GLP-1 receptor antagonist, des His1 Glu9 exendin-4 (10.0 microgram), significantly attenuated LiCl-induced (76 mg/kg; i.p.) c-Fos expression in several brainstem regions, including the area postrema, the nucleus of the solitary tract, and the lateral parabrachial nucleus. While central infusion of des His1 Glu9 exendin-4 also blocked GLP-1-induced (10.0 microgram) anorexia and c-Fos expression, the antagonist produced no independent effects on food intake or c-Fos expression. These results suggest that LiCl-induced c-Fos expression in the rat brainstem is mediated, at least in part, by GLP-1 receptor signaling.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

August 10, 1998

Volume

801

Issue

1-2

Start / End Page

164 / 170

Location

Netherlands

Related Subject Headings

  • Tumor Cells, Cultured
  • Signal Transduction
  • Receptors, Glucagon
  • Rats, Long-Evans
  • Rats
  • Proto-Oncogene Proteins c-fos
  • Peptide Fragments
  • Neurons
  • Neurology & Neurosurgery
  • Male
 

Citation

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Thiele, T. E., Seeley, R. J., D’Alessio, D., Eng, J., Bernstein, I. L., Woods, S. C., & van Dijk, G. (1998). Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem. Brain Res, 801(1–2), 164–170. https://doi.org/10.1016/s0006-8993(98)00584-8
Thiele, T. E., R. J. Seeley, D. D’Alessio, J. Eng, I. L. Bernstein, S. C. Woods, and G. van Dijk. “Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem.Brain Res 801, no. 1–2 (August 10, 1998): 164–70. https://doi.org/10.1016/s0006-8993(98)00584-8.
Thiele TE, Seeley RJ, D’Alessio D, Eng J, Bernstein IL, Woods SC, et al. Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem. Brain Res. 1998 Aug 10;801(1–2):164–70.
Thiele, T. E., et al. “Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem.Brain Res, vol. 801, no. 1–2, Aug. 1998, pp. 164–70. Pubmed, doi:10.1016/s0006-8993(98)00584-8.
Thiele TE, Seeley RJ, D’Alessio D, Eng J, Bernstein IL, Woods SC, van Dijk G. Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem. Brain Res. 1998 Aug 10;801(1–2):164–170.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

August 10, 1998

Volume

801

Issue

1-2

Start / End Page

164 / 170

Location

Netherlands

Related Subject Headings

  • Tumor Cells, Cultured
  • Signal Transduction
  • Receptors, Glucagon
  • Rats, Long-Evans
  • Rats
  • Proto-Oncogene Proteins c-fos
  • Peptide Fragments
  • Neurons
  • Neurology & Neurosurgery
  • Male