The role of CNS glucagon-like peptide-1 (7-36) amide receptors in mediating the visceral illness effects of lithium chloride.

Published

Journal Article

Peripheral administration of large doses of lithium chloride (LiCl) to rats causes a spectrum of effects that are consistent with visceral illness. LiCl reduces food intake, decreases salt ingestion after sodium depletion, induces pica, and produces robust conditioned taste aversions. Because some of the effects of peripheral LiCl are mimicked by centrally administered glucagon-like peptide-1 (7-36) amide (GLP-1), we hypothesized that this peptide is involved in the neural pathways by which LiCl causes visceral illness. To test this hypothesis, we pretreated rats with a selective and potent GLP-1 receptor antagonist given directly into the third ventricle via an indwelling cannula before administration of peripheral LiCl. The GLP-1 receptor antagonist completely blocked the effect of LiCl to reduce food intake, induce pica, and produce a conditioned taste aversion. The same dose of GLP-1 receptor antagonist did not reverse the LiCl-induced reduction in NaCl intake. The data indicate a role for GLP-1 receptors in the CNS pathway that mediates some of the effects of visceral illness.

Full Text

Duke Authors

Cited Authors

  • Seeley, RJ; Blake, K; Rushing, PA; Benoit, S; Eng, J; Woods, SC; D'Alessio, D

Published Date

  • February 15, 2000

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 1616 - 1621

PubMed ID

  • 10662851

Pubmed Central ID

  • 10662851

International Standard Serial Number (ISSN)

  • 0270-6474

Language

  • eng

Conference Location

  • United States